Figure 3
From: Anti-HBV efficacy of combined siRNAs targeting viral gene and heat shock cognate 70
Specific inhibition of HBV genes by siRNA targeting viral gene in combination with siHsc70 in HepG2.2.15 cells. (A) The inhibition of HBVS mRNA by siRNAs at different time points. HepG2.2.15 cells were transfected with pU6, S1, S2, siHsc70, S2 with siHsc70, and also the heterologous S3. Data represent means±SD from three independent experiments were performed in triplicate. *Significant differences compared to the heterologous siRNA control: Student’s t-test; P < 0.05. (B) Inhibition of HBV DNA by siRNAs in cell culture supernatants. HepG2.2.15 cells were transfected with pU6, S1, S2, siHsc70, S2 with siHsc70, and also the heterologous S3. Data represent means±SD from three independent experiments were performed in triplicate.