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Table 3 Genotype frequency of toll-like receptor (TLRs) polymorphisms in children with pandemic A/H1N1 influenza infection by disease severity

From: Toll-like receptor 3 gene polymorphisms and severity of pandemic A/H1N1/2009 influenza in otherwise healthy children

Polymorphism genotypes

A/H1N1/2009-positive children hospitalised because of pneumonia(n=18)

A/H1N1/2009-positive children discharged with a diagnosis other than pneumonia(n=33)

 

Frequency

Viral load (mean log10cp/mL ± SD)

Frequency

Viral load (mean log10cp/mL ± SD)

TLR2 rs5743708

 GG

17 (94.4)

7.43 ± 1.30

32 (97.0)

7.06 ± 1.57

 GA

1 (5.6)

3.88

1 (3.0)

8.29

p-value, HWE

0.90

 

0.93

 

TLR3 rs5743313

 CC

0 (0.0)*

NA

26 (78.8)

6.94 ± 1.45

 TT

0 (0.0)

NA

4 (12.1)

7.24 ± 2.42

 CT

18 (100.0)*

7.23 ± 1.51

3 (9.1)

8.07 ± 1.33

p-value, HWE

<0.001

 

<0.001

 

TLR3 rs5743315

 CC

15 (83.3)

7.26 ± 1.66

31 (93.9)

7.12 ± 1.59

 AC

3 (16.7)

7.10 ± 0.36

2 (6.1)

6.69 ± 1.25

p-value, HWE

0.70

 

0.86

 

TLR4 rs4986790

 AA

16 (88.9)

7.12 ± 1.53

30 (90.9)

7.00 ± 1.56

 AG

2 (11.1)

8.14 ± 1.41

3 (9.1)

8.01 ± 1.57

p-value, HWE

0.80

 

0.78

 

TLR4 rs4986791

 CC

17 (94.4)

7.24 ± 1.56

29 (87.9)

7.00 ± 1.56

 TT

0 (0.0)

NA

0 (0.0)

NA

 CT

1 (5.6)

7.14

4 (12.1)

8.01 ± 1.57

p-value, HWE

0.90

 

0.71

 
  1. HWE: Hardy-Weinberg equilibrium; NA: not available; TLR: toll-like receptor. Percentages in parentheses. *p<0.0001 vs A/H1N1/2009-positive children discharged with a diagnosis other than pneumonia; no other significant between-group difference.