Table 1 Fundamental information of 119 differentially expressed protein spots identified by MS

Actin cytoskeleton and cellular structural proteins

3908

collagen alpha-1(VI) chain precursor

−1.05

1.57

1.44

4.53**

3.47**

1.14

−1.65

gi|49225581

107916.8

5.63

3910

collagen alpha-1(VI) chain precursor

1.32

2.92**

−1.66

3.77**

3.72*

−1.73

1.06

gi|49225581

107916.8

5.63

3914

collagen alpha-2(VI) chain precursor

1.01

1.79

1.54

4.11**

−1.2

1.35

−1.01

gi|45384382

109108.4

5.66

3915

collagen alpha-2(VI) chain precursor

−1.33

2.24**

1.4

3.58**

1.71

1.89

1.09

gi|45384382

109108.4

5.66

508

keratin, type I cytoskeletal 15

−1.22

−1.17

1.06

2.67**

1.28

−1.02

−1.03

gi|47604932

48060.8

5.11

6713

keratin, type II cytoskeletal 1

−1.03

−1.68

1.23

−2.25**

−1.43

−1.2

−1.69

gi|119395750

65999

8.15

4502

keratin, type II cytoskeletal cochleal

1.69

−1.15

−2.55**

−1.2

1.64

1.42

−1.23

gi|45384378

53770.5

5.97

106

Chain B, Refined 1.8 Angstroms Resolution Crystal Structure Of Porcine Epsilon-Trypsin

1.34

−1.31

−1.14

−2.62**

−2.28**

−2.63**

−1.29

gi|999627

8813.5

6.67

9222

PREDICTED: LOW QUALITY PROTEIN: keratin, type II cytoskeletal 1-like

AB

IN

AB

AB

AB

AB

AB

gi|296211766

66379

8.16

6206

REDICTED: similar to Chain D, Crystal Structure Of Arp23 COMPLEX

1.08

1.34

1.07

−1.04

−1.08

1.21

2.14**

gi|118093746

34379.6

6.84

6211

PREDICTED: similar to Chain D, Crystal Structure Of Arp23 COMPLEX

−2.11**

3.72**

1.09

4.76**

2.22**

4.28**

1.73

gi|118093746

34379.6

6.84

314

beta-tropomyosin

−1.19

1.04

1.37

1.82

1.66

2.86**

1.43

gi|212809

32779.7

4.77

6601

fibrinogen beta chain precursor

−1.37

1.28

−1.01

1.88

2.33**

−1.2

−1.44

gi|267844833

54545.7

7.84

2606

plastin-2

−1.65

2.04**

1.23

2.44**

2.24*

2.13**

1.27

gi|56605886

69704.5

5.16

2206

beta-actin

−1.1

1.87

1.08

1.06

1.53

2.08**

2.2**

gi|154818367

41812.8

5.32

3906

collagen alpha-1(VI) chain precursor

−1.07

1.67

1.51

4.29**

1.68

1.55

−1.61

gi|49225581

107916.8

5.63

Enzymes

4406

adenylosuccinate synthetase isozyme 2

−1.29

1.1

−1.39

2.19*

2.2*

−1.46

−1.16

gi|71895783

49423.4

5.93

4410

argininosuccinate synthase

1.48

1.56

1.49

IN

3.99

2.64**

−1.2

gi|61657937

46873.8

6.1

5402

argininosuccinate synthase

−1.63

4.04**

1.03

1.15

1

1

−1.45

gi|61657937

46873.8

6.1

5904

argininosuccinate synthase

1.35

2.49**

1.22

1.82

1.83

−1.23

−1.67

gi|61657937

46873.8

6.1

6705

ATP-dependent RNA helicase DDX3X

−1.03

−1.33

1.15

−2.2**

−2.27**

1

−1.55

gi|71895253

72004.5

6.54

3414

B-creatine kinase

−1.32

1.73

−1.3

2.09**

1.76

1.34

−1.08

gi|211235

42240.4

5.78

7213

L-lactate dehydrogenase A chain

−1.08

1.71

−1.03

2.36**

2.63**

2.43**

−1.4

gi|45384208

36491.2

7.75

6606

phosphoglucomutase 2

AB

REP

REP

−1.36

AB

−1.4

1.29

gi|71897287

67900.1

6.56

9221

PREDICTED: similar to 2,4-dienoyl-CoA reductase

AB

IN

AB

AB

AB

AB

AB

gi|50731694

35723.5

9.46

3205

PREDICTED: similar to pyridoxal kinase

AB

1.56

1.45

2.74*

2.02**

2.45**

−1.04

gi|118083963

43075.8

8.36

3207

RecName: Full=3-mercaptopyruvate sulfurtransferase; Short=MST

AB

AB

IN

AB

AB

AB

AB

gi|90110410

33002.5

6.11

6107

RecName: Full=Carbonic anhydrase 2; AltName:

−1.13

−1.45

1.13

1.38

3.04

1.19

2.22*

gi|115454

29388.4

6.56

Full=Carbonate dehydratase II; AltName: Full=Carboni anhydrase II; Short=CA-II

2622

PREDICTED: similar to serine/threonine kinase isoform 1

AB

1.17

1.44

REP

−1.22

−1.43

−2.46**

gi|118094908

57883.8

6.04

4117

PREDICTED: similar to Glyoxylase 1

REP

AB

AB

AB

AB

AB

AB

gi|50740506

20540.2

6.1

6402

creatine kinase M-type

AB

1.16

1.32

2.64*

2.68**

2.47**

−1.04

gi|45382875

43301

6.5

6408

creatine kinase M-type

−1.39

2.07*

1.75

6.7**

1.14

2.27

−1.06

gi|45382875

43301

6.5

6414

enolase

1.24

1.18

1.28

1.59

2.38**

1.4

1.25

gi|116248308

41047.2

5.62

9101

glutathione S-transferase

1.04

1.99

1.39

2.47**

2.7**

2.58**

−1.13

gi|49169816

25282.4

8.86

4210

PREDICTED: gemin 4

−1.58

1.18

1.56

−1.24

1.07

−2.17**

−1.37

gi|224076562

30154.9

4.96

1109

cathepsin B precursor

1.02

−1.03

1.04

2.27**

2.39**

2.86**

1.04

gi|46195455

37562.7

5.74

5607

peptidase D

−1.39

1.49

IN

1.73

IN

2.08**

−1.21

gi|169139269

55101.6

6.07

9111

peptidyl-prolyl cis-trans isomerase B precursor

1.15

1.55

1.12

2**

1.78

1.88

−1.17

gi|45382027

22398.8

9.4

6111

PREDICTED: similar to Glutathione S-transferase theta 1 isoform 3

1.55

−1.1

−1.59

−2.38**

−1.56

−3.36**

1.13

gi|118098704

27843.7

6.25

Immunity, apoptosis, tumor development and viral infection and replication

6507

septin-6

−1.15

−1.27

−6.03**

−1.82

−1.35

−1.39

1.2

gi|71895629

48656.9

6.67

6521

septin-6

1.1

1.25

2.42**

−1.3

−1.05

−1.15

−1.55

gi|71895629

43021.1

6.63

7310

septin-9

−1.08

−1.38

−1.08

−2.87**

−2.09*

−2.33*

−1.25

gi|71897123

65482.8

8.42

3203

PREDICTED: similar to PTB-associated splicing factor

AB

AB

−2.1**

AB

−2.75**

−1.09

2.06**

gi|118101662

69173.9

9.43

7116

PREDICTED: heterogeneous nuclear ribonucleoprotein A3

−1.97

2.16**

−1.67

11.96**

2.33**

2.4**

1.4

gi|118093536

40603.2

9.24

8310

PREDICTED: heterogeneous nuclear ribonucleoprotein A3

AB

AB

AB

−6.86**

AB

AB

AB

gi|118093536

40603.2

9.24

1310

PREDICTED: heterogeneous nuclearribonucleoproteins C1/C2-like

−1.22

−1.19

−1.04

−3.14**

−2.43*

−1.36

1.29

gi|296224780

23551.2

9.87

8304

heterogeneous nuclear ribonucleoprotein A/B

1.02

1.29

−1.92

−2.39**

−2.58**

−2.11**

−1.18

gi|45384514

31841.8

8.62

2613

heterogeneous nuclear ribonucleoprotein H

−1.14

−1.78

1.87

−2.13**

−3.36

−2.48

1.05

gi|45383173

56530.6

5.38

2610

heterogeneous nuclear ribonucleoprotein H

1.22

−2.25*

−1.31

AB

−2.11**

−1.82

−2.91

gi|45383173

56530.6

5.38

3101

heterogeneous nuclear ribonucleoproteins A2/B1

1.69

1.46

−1.39

−1.6

−2.00**

1.79

1.07

gi|71896753

36962.4

8.67

8211

heterogeneous nuclear ribonucleoproteins A2/B1

−1.1

−1.11

1.06

−2**

−2**

−1.68

−1.12

gi|71896753

36962.4

8.67

8213

heterogeneous nuclear ribonucleoproteins A2/B1

1.04

−1.07

−1.46

−2.53**

−1.41

−2.01**

−1.1

gi|71896753

36962.4

8.67

9205

heterogeneous nuclear ribonucleoproteins A2/B1

−1.08

1.07

−1.41

−2.47**

−2.19**

−1.57

−1.12

gi|71896753

36962.4

8.67

7006

macrophage migration inhibitory factor

1.35

−1.03

−2.04**

−1.64

−1.77

−1.84

1.74

gi|212258

12704.2

6.88

2905

heat shock protein HSP 90-alpha

−1.37

−1.55

−1.23

−3.73**

−1.58

−1.63

−1.67

gi|157954047

84006.5

5.01

7215

annexin A1

AB

IN

1

IN

IN

IN

AB

gi|46195459

38475.9

7.05

7703

far upstream element-binding protein 1

1.03

−2.56

1.34

−2.53**

−2.38*

−1.85

−1.48

gi|83320094

67155.3

7.18

3014

stathmin

1.19

1

−1.16

−4.27**

−7.72**

−7.18**

1.05

gi|50053682

17071.9

6.18

4003

stathmin

1.1

−2.1**

−1.1

−4.91**

−4.49**

−5.08**

−1.1

gi|50053682

17071.9

6.18

405

vimentin

−1.5

3.27*

1.56

3.31**

1.36

1.06

1.04

gi|114326309

53109.6

5.09

1605

vimentin

1.62

1.76

1.77

2.9**

−1.35

−1.08

−1.01

gi|114326309

53109.6

5.09

409

vimentin

1.23

1.64

1.42

2.26**

1.47

1.31

1

gi|114326309

53109.6

5.09

205

nucleolar protein B23/No38

1.28

1.76

−1.51

1.54

1.58

1.65

6.95**

gi|212456

10716.2

4.38

6003

beta-galactoside-binding lectin

1.07

2.22**

1.56

2.7**

2.66**

2.4**

−1.45

gi|45382785

15053.5

6.58

3113

PREDICTED: similar to natural killer cell enhancing factor isoform 4

1.63

1.12

1.63*

1.58

2.5**

2.28**

−1.27

gi|50751518

22300.5

8.24

5304

unnamed protein product

1.23

1.88

1.45

−1.49

−1.26

1.28

2.11**

gi|74142813

50433.1

6.17

1104

PREDICTED: similar to interferon, gamma-inducible protein 30

1.14

−1.05

−1.04

−2.27**

−1.29

−1.12

1.19

gi|50761132

14269.9

5.73

401

mCG49244

1.23

−1.56

1.27

−2.25*

−2.04**

−1.63

−1.73

gi|148694498

21747.1

5.71

114

SET

1.62

5.16**

1.18

−1.01

−1.07

1.01

1.51

gi|3953617

24348

4.97

Mitosis, replication and translation

1402

put. beta-actin (aa 27–375)

1.01

−1.27

−2.74**

−13.22**

−14.21**

−1.1

−1.07

gi|49868

39160.6

5.78

2303

suppressor of G2 allele of SKP1 homolog

AB

−2.33*

−1.1

REP

REP

REP

REP

gi|71895155

20497.5

6.35

6307

mitotic checkpoint protein BUB3

AB

−3.53**

1.61

REP

REP

REP

−2.97**

gi|57529813

37256.3

6.5

3501

PREDICTED: similar to eukaryotic translation initiation factor 4H isoform 1

1.26

−2.31*

−1.33

−1.99

−1.45

−1.84

1.02

gi|126314438

27406.4

6.78

8202

PREDICTED: similar to eukaryotic translation initiation factor 4H isoform 1

1.17

−3.81**

1.13

−2.86**

−1.72

−1.38

−2.65**

gi|126314438

27406.4

6.78

2013

PREDICTED: similar to histone H2B

3.97*

REP

REP

REP

REP

REP

8.73**

gi|149617840

29704.7

9.68

7117

single-strand binding protein

AB

AB

AB

IN

IN

IN

AB

gi|42523087

15766.8

6.13

5603

pre-mRNA-processing factor 19

1.61

−1.34

−2.62**

−1.23

−1.09

−1.32

−1.16

gi|86129600

55100.2

6.19

Signal transduction

3616

Amb7

1.22

1.9

1.94

4.4**

1.87

IN

AB

gi|117168610

225516.8

5.61

5518

coronin-1C

AB

AB

AB

IN

AB

AB

AB

gi|86129440

53174.1

6.22

6102

coronin-1C

−1.1

1.32

−1.33

2.41**

3.78*

3.37**

3.76**

gi|86129440

53174.1

6.22

3015

fatty acid-binding protein, adipocyte

−2.05**

2.38*

2.34**

4.91**

4.73**

2.39**

1.11

gi|45383556

14884.6

6.34

3012

fatty acid-binding protein, heart

−1.23

−1.49

AB

9.97**

1.5

1.62

1.77

gi|71894843

14806.6

5.92

3709

Lipocalin precursor

1.75

−1.47

1.09

4.11**

6.62**

3.26*

1.47

gi|225716896

20257.1

7.6

6213

PREDICTED: similar to GADS protein

−1.46

−1.24

1.56

−2.49**

1.7

−1.08

1.19

gi|118082689

33178.5

6.23

5205

PREDICTED: similar to GADS protein

−1.11

−2.14**

−1.15

−3.84**

1.04

−1.16

−1.45

gi|118082689

33178.5

6.23

6310

PREDICTED: similar to nucleic acid binding protein isoform 2

1.42

−1.6

−1.03

−1.41

−2.07**

−1.59

−1.63

gi|126345445

35784.3

7

6011

PREDICTED: similar to retinoid binding protein 7

−4.75**

IN

IN

IN

IN

4.34**

AB

gi|118101075

14701.2

5.31

1008

thioredoxin

−1.26

−1.11

−1.02

2.46*

1.28

1.7

1.07

gi|45382053

11692.8

5.1

Transport

6517

ferritin heavy chain

−1.14

2.81**

−1.44

2.13**

4.11**

2.25**

1.02

gi|45384172

21078.3

5.78

7203

ferritin heavy chain

−4.57**

1.42

−1.18

3.89**

2.12**

2.49**

1.03

gi|45384172

21078.3

5.78

8018

hemoglobin alpha-A chain

−3.13**

1.13

1.41

1.37

1.2

1.4

1.26

gi|4894665

10914.7

7.19

8003

hemoglobin alpha-A chain

−2.54**

−1.15

−1.12

−1.03

1.28

−1.14

1.06

gi|4894665

10914.7

7.19

6009

hemoglobin subunit alpha-D

−1.08

−1.07

3.59**

1.2

1.02

1.04

1.03

gi|52138645

15685

7.01

6804

ovotransferrin BB type

1.03

1.32

−1.27

2.71*

1.82

1.78

1.03

gi|71274075

77781.4

6.85

6810

ovotransferrin BB type

AB

1.95

REP

20.2*

IN

IN

AB

gi|71274075

77781.4

6.85

6801

ovotransferrin CC type

1.56

1.27

1.19

2.52**

2.89*

2.48*

−1.17

gi|71274077

77750.4

7.08

7201

mediator of cell motility 1

1.37

−1.06

1.02

−2.93**

−1.09

1.54

−1.24

gi|300676818

31517.5

6.49

Others proteins

6104

603815993F1 CSEQCHN52 Gallus gallus cDNA clone ChEST809j23 5′, mRNA sequence

1.14

−1.17

−1.57

−2.53**

−2.12**

−1.94

1.19

gi|25541234

23338.9

6.03

304

alpha-tropomyosin (partial)

−1.32

1.18

1.12

2.37**

2.38**

2.46**

1.71

gi|212815

30045.3

4.64

5815

conalbumin

−1.17

1.11

−1.05

5.97*

3.44**

1.9

−1.12

gi|295721

79551.1

6.85

4012

cytoChrome c subfamily, putative

AB

IN

AB

IN

IN

26.4

AB

gi|124005227

24128.2

9.21

307

putative nucleophosmin 1 variant 1

1.2

−2.66*

1.23

−2.09**

−3.13**

−1.19

1.06

gi|45383996

32612

4.66

4412

putative protein product of Nbla10058

AB

IN

AB

AB

AB

AB

AB

gi|76879893

48587.2

5.85

204

PREDICTED: similar to Acidic leucine-rich nuclear

1.3

−1.71

−1.6

−2.22*

−3.2**

−2.45**

−1.14

gi|118096008

32075.9

3.98

4420

PREDICTED: similar to cyclophilin

AB

AB

AB

IN

IN

AB

AB

gi|118089782

39402.9

5.61

6304

PREDICTED: similar to KIAA0089

1.01

−1.19

−1.45

−1.43

−2.6**

−1.8

1.2

gi|50732786

38564.1

6.55

4116

PREDICTED: similar to LOC129607 protein

−1.25

IN

AB

IN

IN

IN

AB

gi|118088982

31865.5

8.45

4114

PREDICTED: similar to MGC84496 protein

−1.43

−1.32

−1.37

1.17

1.64

1.98

2.77**

gi|118101652

22693.7

6.07

8002

protein S100-A10

−1.27

1.37

1.11

3.15*

1.27

1.3

1

gi|45382861

11282.5

6.82

1006

transthyretin precursor

−1.12

−1.01

1.35

−2.64**

−3.31**

−1.57

−1.09

gi|45384444

16299.1

5.11

Hypothetical proteins

3507

PREDICTED: hypothetical protein

1.52

−1.52

−1.24

−3.08**

−2.04*

−1.49

−1.31

gi|50762370

47124.5

5.64

2203

PREDICTED: hypothetical protein

−1.37

−1.72

−1.72

−6.61**

−2.27**

−3.83**

−1.02

gi|118087111

30122.5

5.51

2209

PREDICTED: hypothetical protein

−1.12

−1.22

−2.19**

−1.3

−1.27

1.14

1.43

gi|118092623

32616.1

5.53

3110

PREDICTED: hypothetical protein

AB

−2.73**

IN

AB

−3.04**

−2*

−1.22

gi|118084734

18881.6

6.08

5108

PREDICTED: hypothetical protein

−5.55**

REP

REP

−1.2

IN

REP

1.75

gi|118084734

18881.6

6.08

7214

PREDICTED: hypothetical protein

−1.48

1.03

−2.13**

−1.46

1.88

1.06

−1.04

gi|50762370

47124.5

5.64

2307

hypothetical protein

−1.24

1.82

1.47

1.39

1.55

2.28*

2.19**

gi|53126859

42107.9

5.31

4013

hypothetical protein Bsuib36_09931

AB

AB

AB

IN

AB

AB

AB

gi|254704229

122393.8

8.07

3210

hypothetical protein PANDA_003704

AB

AB

AB

IN

AB

AB

AB

gi|281343027

31307.8

5.44