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Table 3 Amino acid variations in the HCV NS3 protein not associated with resistance mutations to HCV NS3 protease

From: Naturally occurring mutations to HCV protease inhibitors in treatment-naïve patients

NS3 Protease positiona

HCV variation in different genotypes (number of sequenced patients)b

NS3 Protease positiona

HCV variation in different genotypes (number of sequenced patients)b

1a (n = 31)

1b (n = 39)

2 (n = 30)

3 (n = 33)

4 (n = 23)

1a (n = 31)

1b (n = 39)

2 (n = 30)

3 (n = 33)

4 (n = 23)

4

    

T4P (14)

67

S67P/A (14)

  

A67V/T (7)

 

5

   

A5T/P (3)

A5G/C(6)

69

   

H69R (2)

 

7

 

S7A (12)

A7T/V (11)

A7T(2)

 

72

I72T/F (2)

T72A/I/L (13)

   

10

    

T10H/N (2)

82

 

L82G (3)

   

11

    

R11P (2)

83

 

V83N/T/I

   

12

    

G12A/R (3)

91

S91A/T (28)

A91S (5)

 

A91T (4)

 

13

    

L13M/W/T (13)

92

 

T95E/S (2)

  

R92K/T (15)

14

 

L14F (5)

 

L14F (3)

F14L/I (15)

95

   

E95D (3)

A95T/S (4)

15

  

D15G (28)

 

S15G (12)

98

   

A/98 T (15)

 

16

  

A16T (8)

  

101

    

S101A (8)

18

I18V (2)

I18V (4)

  

V18I (3)

102

   

S102A (3)

A102S (20)

20

   

S20G (4)

 

105

    

Y105F (14)

24

   

R24K (2)

R24K (3)

107

 

V107I (4)

   

26

 

K26R (3)

   

110

   

D110E (5)

H110N (3)

28

Q28E/L (3)

 

D28E (2)

V28I/M (5)

 

114

I114V (3)

V114I (26)

  

I114V (18)

33

V33I (2)

 

V33I (10)

 

V33I (13)

117

 

R117H/C (4)

   

35

 

V35I (5)

V35I (3)

  

119

  

R119Q (2)

  

39

 

A39T (3)

   

122

S122G (10)

S122T/C (5)

  

T122S (2)

40

A40T/S (9)

    

123

 

R123K (3)

   

42

 

S42T/F (5)

   

127

    

L127I (11)

44

    

L44M (2)

132

 

I132V/M (18)

 

L132I (2)

 

46

 

T46S/A (2)

   

134

  

S134T (13)

  

47

    

A47G/S (2)

146

  

P146S (2)

  

48

I48V (4)

V48I/L (14)

  

V48I (11)

147

 

S147L (2)

 

S147L/A/R/T (5)

M147L/Q (15)

49

 

N49S (2)

   

150

 

V150A (29)

  

R150V/A (20)

51

 

V51A (2)

V51T/A (3)

  

151

    

A151V (3)

56

 

Y56F/C (4)

   

153

 

I153V/L (3)

   

60

 

S60A/T/P (7)

   

166

   

S166A/T (3)

 

61

T61S (2)

K61R (4)

   

174

N174S/G (23)

S174A/L (3)

S174T (2)

  

64

I64L (2)

    

177

  

V177I (3)

  

65

    

S65C (2)

179

   

A179T/V (2)

 
  1. aAmino acid position associated with polymorphisms compared to reference sequences;
  2. bReference strain accession numbers for each genotype: M62321 (1a), D90208 (1b), D50409 (2c), D17763 (3a), and Y11604 (4a).
  3. cLetter on the left represents the wild type amino acid, on the right, the amino acid substitution. The number of patients with mutant HCV strains is indicated in brackets.