Neutralization of IL-22 exacerbated the severity of AVMC on day 14 after infection. A. Representative of myocardial histopathologic images in Anti-IL-22 Ab,IgG control and PBS groups (H&E, original magnification × 400). B. Survival rate was significantly decreased in Anti-IL-22 Ab group. C. The pathological scores in different groups. Each point represented an individual mouse. D. The ratios of HW/BW in different groups. *p< 0.05.