Elevated expressions of IL-22 and IL-22R in AVMC, on day 14 post infection. A. Representative of myocardial histopathologic images in AVMC and control groups (H&E, original magnification × 400). B. Representative of IL-22 immunohistochemistry images in heart tissue (Dark brown granules, original magnification × 400). C. Morphometric quantitation of cardiac IL-22 protein expressions. D. ELISA analysis of IL-22 protein levels in the plasma. E. Relative cardiac expressions of IL-22–IL-22 receptor complex gene were detected by RT-PCR. *p < 0.05, **p < 0.01. Data are mean ± SD. AVMC, Acute Viral Myocarditis.