Table 1 Determination of ATIII treatment effect on gene expression in the context of HCV
Gene | Symbol | Replicon/Non-replicon Gene expression | Replicon/Replicon+7 μM ATIII Gene expression | ||
|---|---|---|---|---|---|
Fold change | P-value | Fold change | P-value | ||
Bone morphogenetic protein 4 | BMP4 | 9.15 | 0.04 | −1.68 | 0.09 |
Cyclin-dependent kinase inhibitor 1A | CDKN1A | 2.61 | 0.03 | −1.64 | 0.1 |
Cyclin-dependent kinase inhibitor 2B | CDKN2B | 10.98 | 0.005 | −1.59 | 0.1 |
Cytochrome P450, family 19, subfamily A, polypeptide 1 | CYP19A1 | 5.70 | 0.002 | −1.73 | 0.01 |
Fatty acid synthase | FASN | 4.01 | 0.01 | −2.87 | 0.9 |
Heat shock 27kDa protein 1 | HSPB1 | 2.82 | 0.001 | −1.21 | 0.6 |
Heat shock protein 90kDa alpha class A member 2 | HSP90AA2 | 4.01 | 0.03 | −1.14 | 0.6 |
Interleukin 4 receptor | IL4R | 4.76 | 0.01 | −1.79 | 0.04 |
Matrix metallopeptidase 10 | MMP10 | 49.29 | 0.006 | −2.19 | 0.3 |
Ornithine decarboxylase 1 | ODC1 | 4.49 | 0.01 | 1.35 | 0.4 |
Retinol binding protein 1 | RBP1 | 2.66 | 0.045 | −1.59 | 0.2 |
WNT1 inducible signaling pathway protein 1 | WISP1 | 6.32 | 0.008 | −1.16 | 0.6 |