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Table 2 Asymptomatic shedding of HSV-1 detected by PCR from mouth swabs (saliva) of healthy subjects

From: HSV-1 latent rabbits shed viral DNA into their saliva

Authors, Year N Individuals: total positive/total subjects Shedding frequency: total positiveswabs/total swabs Mouth swab frequency: numberof swabs/subject
Robinson et al., 1992 [65] 12 12/12 (100%) 0/0 (0%) 0
Robinson et al., 1992 [65] 12* 0/12 (0%) 0/0 (0%) 0
Tateishi et al., 1994 [63] 1000 46/1000 (4.6%) 46/1000 (4.6%) one
Kriesel et al., 1994 [66] 27 3/27 (11%) 3/27 (11%) one
Lee et al., 1996 [67] 87 12/87 (13.8%) 12/87 (13.8%) one
Knaup et al., 2000 [68] 30 19/30 (63.3%) 39/290 (13.5%) 9-10
Druce et al., 2002 [69] 477 43/477 (9%) 43/477 (9%) one
Gleeson et al., 2002 [70] 14 0/14 (0%) 0/0 (0%) 0
Youssef et al., 2002 [71] 5 1/5 (20%) 1/5 (20%) one
Miller et al., 2004 [72] 123 11/123 (8.9%) 11/123 (8.9%) one
Miller et al., 2004 [72] 63** 13/63 (21%) 17/217 (7.8%) 3-4
Kaufman et al., 2005 [73] 50 46/50 (92%) 1020/2712 (37.6%) 54
Miller et al., 2005 [74] 58 1/58 (1.7%) 1/58 (1.7%) one
da Silva et al., 2005 [75] 25 25/25 (100%) 162/309(52.4%) 12-13
Lin et al., 2005 [76] 60 4/60 (6.7%) 4/60 (6.7%) one
Kumar et al., 2009 [77] 14***** 12/14 (86%) 357/840 (42%) 60
Kumar et al., 2009 [77] 15*** 15/15 (100%) 465/900 (52%) 60
Kumar et al., 2009 [77] 16**** 15/16 (94%) 701/961 (73%) 60
Totals 2076 278/2088 (13%) 2882/8066 (36%)  
  1. *Had no clinical history of HSV-1.
  2. **Had dental procedure prior to mouth swab.
  3. *** Received Valtrex treatment + Placebo treatment.
  4. ****Received Valtrex treatment + Aspirin treatment.
  5. ***** Received 2 Placebo treatments.
  6. The Kumar et al., 2009 study was double blind. Placebo and control had trials in healthy adults.