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Table 2 Immunization schedule

From: Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain

Group 1st (day 0) 2nd (day 14) 3rd (day 28) Routesa
1 rADV-Mock rADV-Mock rADV-Mock i.m.
2 rADV-S 2 × 107 rADV-S 2 × 107 rADV-S 2 × 107 i.m.
3 rADV-S 2 × 107 rADV-S 2 × 107 rADV-S 2 × 107 i.n.
4 rADV-S 1 × 108 rADV-S 1 × 108 rADV-S 1 × 108 i.n.
5 rADV-S 2 × 107 rADV-S 2 × 107 rADV-S 2 × 107 s.l.
6 rADV-S 1 × 108 rADV-S 1 × 108 rADV-S 1 × 108 s.l.
  1. a Groups of six BALB/c mice were immunized s.l., i.n., or i.m. with rADV-S three times at 2-week intervals.