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Figure 4 | Virology Journal

Figure 4

From: Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain

Figure 4

Detection of S 366-374 epitope-specific and IFN-γ secreting CD8+T lymphocytes in the mice vaccinated with rADV-S. Mice were immunized three times with rADV-S 1 × 108 PFU by s.l., i.n., or i.m. route. Lung (A) and spleen (B) lymphocytes were harvested 10 days after the final immunization and were tested by flow cytometric analysis after staining with S366-374 tetramer, IFN-γ, CD8 and CD44.

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