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Table 2 Frequency of amino acid substitution in NS5B protein related to resistance to INF/RBV and new inhibitors in HCV Venezuelan isolates compared to worldwide isolates

From: Prevalence of amino acid mutations in hepatitis C virus core and NS5B regions among Venezuelan viral isolates and comparison with worldwide isolates

  Genotypes
  1a 1b 3a
Substitution (related to) V Br U V LA ASIA V LA U
Q309R (INF/RBV) 36/82 (44%) 67/101 (66%) p = 0.004 28/70 (40%) 7/61 (12%) 7/104 (6.7%) 19/335 (5.7%) 9/9 (100%) 20/22 (91%) 21/21 (100%)
D310N (RBV) 11/82 (13%) p = 0.03 4/101 (4%) 3/70 (4%) 1/61 (1.6%) 1/104 (1%) 3/335 (0.9%) 9/9 (100%) 20/22 (91%) 20/21 (95%)
S282T (NI) 0/82 (0%) 0/101 (0%) 0/70 (0%) 0/61 (0%) 0/104 (0%) 0/335 (0%) 0/9 (0%) 0/22 (0%) 0/21 (0%)
C316N (NNI) 0/82 (0%) 0/101 (0%) 0/70 (0%) 11/61 (18%) 18/104 (18%) 307/335 (91.6%) p < 0.001 0/9 (0%) 0/22 (0%) 0/21 (0%)
  1. V: Venezuela; Br: Brazil; LA: Other Latin-American countries (Brazil, Chile, Colombia and/or Argentina); U: USA; Asia: China, Japan, Hong Kong and Taiwan. Numbers in bold refer to mutations found at higher frequency compared to other genotypes or locations. P: Statistical significance of prevalence of mutations in isolates from Venezuela compared to Brazil (for Q309R and D310N) and from Venezuela and Latin America compared to Asia (C316N).