Table 2 Frequency of amino acid substitution in NS5B protein related to resistance to INF/RBV and new inhibitors in HCV Venezuelan isolates compared to worldwide isolates
Genotypes | |||||||||
|---|---|---|---|---|---|---|---|---|---|
1a | 1b | 3a | |||||||
Substitution (related to) | V | Br | U | V | LA | ASIA | V | LA | U |
Q309R (INF/RBV) | 36/82 (44%) | 67/101 (66%) p = 0.004 | 28/70 (40%) | 7/61 (12%) | 7/104 (6.7%) | 19/335 (5.7%) | 9/9 (100%) | 20/22 (91%) | 21/21 (100%) |
D310N (RBV) | 11/82 (13%) p = 0.03 | 4/101 (4%) | 3/70 (4%) | 1/61 (1.6%) | 1/104 (1%) | 3/335 (0.9%) | 9/9 (100%) | 20/22 (91%) | 20/21 (95%) |
S282T (NI) | 0/82 (0%) | 0/101 (0%) | 0/70 (0%) | 0/61 (0%) | 0/104 (0%) | 0/335 (0%) | 0/9 (0%) | 0/22 (0%) | 0/21 (0%) |
C316N (NNI) | 0/82 (0%) | 0/101 (0%) | 0/70 (0%) | 11/61 (18%) | 18/104 (18%) | 307/335 (91.6%) p < 0.001 | 0/9 (0%) | 0/22 (0%) | 0/21 (0%) |