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Table 1 Frequency of amino acid substitution 70Q and 91 M of core protein in HCV Venezuelan isolates compared to worldwide isolates

From: Prevalence of amino acid mutations in hepatitis C virus core and NS5B regions among Venezuelan viral isolates and comparison with worldwide isolates

Genotype Geographic region R70Q substitution L/C91M substitution
1a V 1/27 (3.7%) 0/27 (0%)
  U 1/27 (3.7%) 0/27 (0%)
  J 0/5 (0%) 0/5 (0%)
  Ur 0/3 (0%) 0/3 (0%)
1b V 30/38 (79%) 26/38 (68%)
  U 20/34 (65%) 28/34 (82%)
  Am 50/72 (69%) 54/72 (75%)
  J 32/80 (40%) 25/80 (31%)
  Ch 7/70 (10%) 43/70 (61%)
  As 39/150 (26%) 68/150 (45%)
   p < 0.001 p < 0.001
2a J 0/66 (0%) 0/66 (0%)
2b V 0/3 (0%) 0/3 (0%)
  J 0/32 (0%) 0/32 (0%)
2c V 0/7 (0%) 0/7 (0%)
  RW 0/20 (0%) 0/20 (0%)
2j V 0/42 (0%) 0/42 (0%)
3a V 1/10 (10%) 0/10 (0%)
  RW 2/18 (11%) 0/18 (0%)
  1. V: Venezuela; U: USA; Ur: Uruguay; Am: American countries (USA and Venezuela). As: Asian countries like Ch: China and J: Japan (including prevalence data of Furui et al. [39], for which sequences are not available); RW: Rest of the world. Numbers in bold refer to mutations found at higher frequency compared to other genotypes or locations. P: Statistical significance of prevalence of mutations in isolates from the Americas compared to Asia.