Prevalence of amino acid mutations in hepatitis C virus core and NS5B regions among Venezuelan viral isolates and comparison with worldwide isolates

Table 1 Frequency of amino acid substitution 70Q and 91 M of core protein in HCV Venezuelan isolates compared to worldwide isolates

Genotype	Geographic region	R70Q substitution	L/C91M substitution
1a	V	1/27 (3.7%)	0/27 (0%)
	U	1/27 (3.7%)	0/27 (0%)
	J	0/5 (0%)	0/5 (0%)
	Ur	0/3 (0%)	0/3 (0%)
1b	V	30/38 (79%)	26/38 (68%)
	U	20/34 (65%)	28/34 (82%)
	Am	50/72 (69%)	54/72 (75%)
	J	32/80 (40%)	25/80 (31%)
	Ch	7/70 (10%)	43/70 (61%)
	As	39/150 (26%)	68/150 (45%)
		p < 0.001	p < 0.001
2a	J	0/66 (0%)	0/66 (0%)
2b	V	0/3 (0%)	0/3 (0%)
	J	0/32 (0%)	0/32 (0%)
2c	V	0/7 (0%)	0/7 (0%)
	RW	0/20 (0%)	0/20 (0%)
2j	V	0/42 (0%)	0/42 (0%)
3a	V	1/10 (10%)	0/10 (0%)
	RW	2/18 (11%)	0/18 (0%)

V: Venezuela; U: USA; Ur: Uruguay; Am: American countries (USA and Venezuela). As: Asian countries like Ch: China and J: Japan (including prevalence data of Furui et al. [39], for which sequences are not available); RW: Rest of the world. Numbers in bold refer to mutations found at higher frequency compared to other genotypes or locations. P: Statistical significance of prevalence of mutations in isolates from the Americas compared to Asia.

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