Multiple linear epitopes (B-cell, CTL and Th) of JEV expressed in recombinant MVA as multiple epitope vaccine induces a protective immune response

Table 2 The diagram of mouse immunization

Groups		Priming	Boost 1	Boost 2
rMVA-mep	10⁵TCID₅₀	10⁶ TCID₅₀/0.1 mL	10⁶ TCID₅₀/0.1 mL	10⁶ TCID₅₀/0.1 mL
	10⁶ TCID₅₀	10⁷ TCID₅₀/0.1 mL	10⁷ TCID₅₀/0.1 mL	10⁷ TCID₅₀/0.1 mL
	10⁷ TCID₅₀	10⁸ TCID₅₀/0.1 mL	10⁸ TCID₅₀/0.1 mL	10⁸ TCID₅₀/0.1mL
Inactivated JEV vaccine		0.1 mL (2x10⁶pfu)	0.1 mL(2x10⁶pfu)	0.1 mL(2x10⁶pfu)
EDIII		50 μg CFA	50 μg IFA	50 μg IFA
rMEP		50 μg CFA	50 μg IFA	50 μg IFA
PBS		0.1 mL	0.1 mL	0.1 mL
Wild MVA		0.1 mL(2x10⁶pfu)	0.1 mL(2x10⁶pfu)	0.1 mL(2x10⁶pfu)

ISSN: 1743-422X