Isolation and mutation trend analysis of influenza A virus subtype H9N2 in Egypt

Table 5 Amino acid residues of the H9N2 viruses that correlate with replication in mammals in comparison to A/chicken/Egypt/BSU-CU/2011 residues

Gene	Residue No.	Non Virulent^a	Virulent^a	A/ck/Eg/BSU-CU/11	Egypt H9N2 2006^b	Middle East H9N2^c
PA	672	F	L	L	L	L
NP	398	K	Q	Q	Q	Q
M1	195	A	S	S	S	S
M2	14	E	G	E	G	E³⁰A³G⁵⁹
NS1	25	R	Q	Q	Q	Q
	225	A	T	T	T	A^1LR^1rT⁶⁹
NS2	14	T	M/I/K	M	M	K⁴M³¹L⁵V²Q²

^aVirulent and non virulent amino acid residues refer to the ability of the virus to replicate in mice as determined by Li et al. [51].
^bA/avian/Egypt/920431/2006(H9N2)) is GenBank available data. The strain isolated from live bird market in Egypt (unpublished report).
^cAll available H9N2 sequences from the Middle East. The available H9N2 sequences include strains from Emirates, Iran, Israel, Jordan, Lebanon, Saudi Arabia and Tunisia found in the Flu database.
Numerical superscripts refer to the number of strains that possess those residues.

ISSN: 1743-422X