Isolation and mutation trend analysis of influenza A virus subtype H9N2 in Egypt

Table 2 Comparison of amino acid signatures in selected genes of avian and human strains to Egyptian H9N2 and H5N1 strains

Gene	Residue	Avian^a	Human^a	H1N1 Pandemic		Egyptian H5N1	A/ck/Eg/BSU-CU/11	Egypt. H9N2 2006^b	Middle East H9N2^c
Gene	Residue	Avian^a	Human^a	2009	1918	Egyptian H5N1	A/ck/Eg/BSU-CU/11	Egypt. H9N2 2006^b	Middle East H9N2^c
PB2	588	A²⁰³/T⁶/V⁶	I⁸³⁵/V³/A²	T	A	A³²/T¹	A	A	A⁸²/V¹⁰/I¹
	613	V²¹²/A³	T⁸¹⁶/I¹⁶/A⁸/V¹	V	V	V³³	V	V	V⁹²/I¹
	627	E¹⁹⁶/K¹⁹	K⁸³⁸/R²/E¹	E	K	K³²/E1	V	E	V⁶⁰/E³¹/A²
	674	A²⁰⁴/S⁶/T²/G²/E¹	T⁸³⁶/A²/I²/P¹	A	A	A³³	A	A	A⁸⁸/T⁵
PB1	327	R¹⁴⁷/K³	K⁷⁶⁶/R⁶⁶	R	R	R³⁵	R	R	R⁸¹
	336	V¹⁴²/I⁸	I⁷⁷³/V⁵⁹	I	V	V³⁵	V	V	V⁸¹
NP	283	L³⁷²/P¹	L⁷/P⁶⁴³	L	P	L³³	L	L	L⁷⁸
	293	R³⁷¹/K²	R²⁸/K⁶²²	R	R	R³²/K¹	R	R	R⁷⁸
	305	R³⁶⁹/K⁴	K⁶³⁶/R¹⁴	F	L	R³³	R	R	R⁷⁸
	313	F³⁷¹/I¹/L¹	Y⁶⁴²/F⁸	V	Y	F³³	F	F	F⁷⁸
	357	Q³⁶⁸/K⁴/T¹	K⁴⁴/R⁸/Q¹	K	K	Q³³	Q	Q	Q⁷⁶/K²
	372	E³⁵⁷/D¹⁵/K¹	D⁶³⁰/E²³	E	E	E³³	E	E	E⁷²/D⁶
	422	R³⁷³	K⁶³⁰/R²³	R	R	R³³	R	R	R⁷⁸
	442	T³⁷²/A¹	A⁶²⁹/T²³/R¹	T	T	T³³	T	T	T⁷⁸
	455	D³⁷³	E⁶³⁰/D²²/T¹	D	D	D³²/E¹	D	D	D⁷⁸
M1	115	V⁸⁵⁶/I²/L¹/G¹	I⁹⁸¹/V⁹	V	V	V³⁵	V	V	V⁹⁴
	121	T⁸⁴⁰/A¹⁹/P¹	A⁹⁸⁸/T²	T	A	T³⁵	T	T	T⁹⁴
	137	T⁸⁵⁹/A¹/P¹	A⁹⁷⁴/T¹²	T	T	T³⁵	T	T	T⁹⁴
M2	11	T⁴³⁴/I¹¹/S²	I⁹¹¹/T⁴⁴	T	T	T³⁵	T	T	T⁹⁰/S¹
	20	S⁴⁷¹/N¹³	N⁹²⁶/S²⁹	S	N	S³⁵	S	S	S⁸³N⁶G¹
	57	Y⁴⁸¹/C¹/H¹	H⁹¹³/Y³³/R²/Q¹	Y	Y	Y³⁵	Y	Y	Y⁸⁷H²
NS2	70	S⁴⁵³/G²¹/D¹	G⁹⁰³/S²	G	S	S⁵²/G⁷	S	S	S⁸³G¹³

^aAvian and human amino acid signatures in different viral genes of influenza A viruses as previously determined [26].
^bA/avian/Egypt/920431/2006(H9N2)) is GenBank available data. The strain isolated from live bird market in Egypt (unpublished report).
^cAll available H9N2 sequences from the Middle East. The available H9N2 sequences include strains from Emirates, Iran, Israel, Jordan, Lebanon, Saudi Arabia and Tunisia found in the Flu database.
Numerical superscripts refer to the number of strains that possess those residues.

ISSN: 1743-422X