Skip to main content

Table 2 Infectious marks of the four tree shrews suspected as chronic-infection*

From: Experimental chronic hepatitis B infection of neonatal tree shrews (Tupaia belangeri chinensis): A model to study molecular causes for susceptibility and disease progression to chronic hepatitis in humans

Animal No. HBV-infection marker Weeks after inoculation
   12w 24w 36w 48w 60w 72w or later
117 serum HBV DNA - - - - / 1.4 × 103
  liver HBV DNA - - - - / 3.3 × 104
  HBsAg 0.17 - - - / 0.09
  HBsAb + - ±− - / -
121-2 serum HBV DNA - - - 4.1 × 103 / /
  liver HBV DNA - - 8.2 × 104 4.1 × 104 / /
  HBsAg 0.3 - - - / /
  HBsAb - ± - - / /
122-2 serum HBV DNA - - - - - -
  liver HBV DNA 1.1 × 105 1.9 × 104 - - - 7.3 × 104
  HBsAg 0.23 - - - - -
  HBsAb + ± ± - - -
140-3 serum HBV DNA - - / - / /
  liver HBV DNA 3.4 × 104 3.1 × 104 / 5.9 × 104 / /
  HBsAg - - / - / /
  HBsAb + - / - / /
  HBcAb + - / - / /
  1. *: The criteria for the animals suspected of persistent infection was as following: The animals that up to the last time of tests (48 weeks or longer after inoculation), showed more than twice weakly positive HBsAg in serum, HBV DNA copy number ≥103 in serum or ≥ 104 in liver tissue. Meanwhile, their serum HBsAb were negative continuously, or were only occasionally positive at the early stage after inoculation.