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Table 2 Infectious marks of the four tree shrews suspected as chronic-infection*

From: Experimental chronic hepatitis B infection of neonatal tree shrews (Tupaia belangeri chinensis): A model to study molecular causes for susceptibility and disease progression to chronic hepatitis in humans

Animal No.

HBV-infection marker

Weeks after inoculation

  

12w

24w

36w

48w

60w

72w or later

117

serum HBV DNA

-

-

-

-

/

1.4 × 103

 

liver HBV DNA

-

-

-

-

/

3.3 × 104

 

HBsAg

0.17

-

-

-

/

0.09

 

HBsAb

+

-

±−

-

/

-

121-2

serum HBV DNA

-

-

-

4.1 × 103

/

/

 

liver HBV DNA

-

-

8.2 × 104

4.1 × 104

/

/

 

HBsAg

0.3

-

-

-

/

/

 

HBsAb

-

±

-

-

/

/

122-2

serum HBV DNA

-

-

-

-

-

-

 

liver HBV DNA

1.1 × 105

1.9 × 104

-

-

-

7.3 × 104

 

HBsAg

0.23

-

-

-

-

-

 

HBsAb

+

±

±

-

-

-

140-3

serum HBV DNA

-

-

/

-

/

/

 

liver HBV DNA

3.4 × 104

3.1 × 104

/

5.9 × 104

/

/

 

HBsAg

-

-

/

-

/

/

 

HBsAb

+

-

/

-

/

/

 

HBcAb

+

-

/

-

/

/

  1. *: The criteria for the animals suspected of persistent infection was as following: The animals that up to the last time of tests (48 weeks or longer after inoculation), showed more than twice weakly positive HBsAg in serum, HBV DNA copy number ≥103 in serum or ≥ 104 in liver tissue. Meanwhile, their serum HBsAb were negative continuously, or were only occasionally positive at the early stage after inoculation.