Skip to main content

Table 1 Infectious marks of the six tree shrews confirmed as chronic-infection

From: Experimental chronic hepatitis B infection of neonatal tree shrews (Tupaia belangeri chinensis): A model to study molecular causes for susceptibility and disease progression to chronic hepatitis in humans

No. Infection marker Weeks after inoculation
   12 24 36 48 60 72 175w 228w
90-1 serum HBV DNA / / / / / / 5.10 × 103 4.00 × 104
  liver HBV DNA 1.09 × 106 1.41 × 106 8.05 × 105 / / / 5.52 × 107 1.71 × 108
  HBsAg / / / / / / 495.50 628.99
  HBsAb / / / / / / - -
  HBeAg / / / / / / + -
  HBeAb / / / / / / - -
  HBcAb / / / / / / - -
97-1 serum HBV DNA - 5.10 × 104 1.20 × 104 6.70 × 103 5.64 × 104 1.40 × 104   
  liver HBV DNA 1.70 × 105 2.50 × 107 3.10 × 107 4.40 × 107 1.08 × 108 8.89 × 108   
  HBsAg / / / / / 281.60   
  HBsAb / / / / / -   
  HBeAg / / / / / -   
  HBeAb / / / / / +   
  HBcAb / / / / / +   
98-2 serum HBV DNA - 3.10 × 104 7.10 × 104 4.01 × 102 2.81 × 104 9.48 × 102   
  liver HBV DNA 3.50 × 106 1.00 × 107 2.30 × 107 2.36 × 107 4.26 × 106 1.53 × 107   
  HBsAg / / / / / 380.00   
  HBsAb / / / / / -   
  HBeAg / / / / / +   
  HBeAb / / / / / -   
  HBcAb / / / / / +   
121-1 serum HBV DNA 8.74 × 102 3.04 × 102 1.24 × 103 9.8 × 103 7.37 × 101 4.99 × 105   
  liver HBV DNA 1.61 × 104 6.88 × 107 8.13 × 108 2.50 × 107 5.37 × 106 2.68 × 108   
  HBsAg 0.14 111.97 424.00 334.12 260.92 380.99   
  HBsAb - - - - - -   
  HBeAg - + + + - +   
  HBeAb - - - - - -   
  HBcAb - - + + + +   
122-1 serum HBV DNA 1.11 × 103 - - 9.68 × 102 2.06 × 102 3.73 × 105   
  liver HBV DNA 3.05 × 104 7.12 × 103 1.27 × 104 3.23 × 104 1.10 × 107 1.82 × 108   
  HBsAg 0.18 - - - 3.78 -   
  HBsAb + ± ± - - -   
  HBeAg - - - - - -   
  HBeAb - - - - - -   
  HBcAb - - - - - -   
123-3 serum HBV DNA - 1.29 × 103 - 8.46 × 102 3.63 × 103 6.56 × 105   
  liver HBV DNA 6.36 × 104 3.07 × 104 4.19 × 104 1.12 × 105 1.92 × 108 1.16 × 108   
  HBsAg ± 11.47 3.47 + + 395.43   
  HBsAb - - - - - -   
  HBeAg ± - - - - +   
  HBeAb - - - - - -   
  HBcAb - - - - +    
  1. HBV DNA in serum and liver samples was detected by FQ-PCR, the result of HBV DNA in serum was expressed as copy/ml, in liver was expressed as copy/μg liver DNA. Serum HBsAg was detected by ELISA and TRFIA, while HBsAb, HBeAg, HBeAb and HBcAb were detected by ELISA only. The results of ELISA were expressed as “+” (positive), “-” (negative) or “±” (between positive and negative). The result of TRFIA was expressed as ng/ml. “/” Indicated there was no test at that time point.