Table 1 Infectious marks of the six tree shrews confirmed as chronic-infection
No. | Infection marker | Weeks after inoculation | |||||||
|---|---|---|---|---|---|---|---|---|---|
12 | 24 | 36 | 48 | 60 | 72 | 175w | 228w | ||
90-1 | serum HBV DNA | / | / | / | / | / | / | 5.10 × 103 | 4.00 × 104 |
liver HBV DNA | 1.09 × 106 | 1.41 × 106 | 8.05 × 105 | / | / | / | 5.52 × 107 | 1.71 × 108 | |
HBsAg | / | / | / | / | / | / | 495.50 | 628.99 | |
HBsAb | / | / | / | / | / | / | - | - | |
HBeAg | / | / | / | / | / | / | + | - | |
HBeAb | / | / | / | / | / | / | - | - | |
HBcAb | / | / | / | / | / | / | - | - | |
97-1 | serum HBV DNA | - | 5.10 × 104 | 1.20 × 104 | 6.70 × 103 | 5.64 × 104 | 1.40 × 104 | ||
liver HBV DNA | 1.70 × 105 | 2.50 × 107 | 3.10 × 107 | 4.40 × 107 | 1.08 × 108 | 8.89 × 108 | |||
HBsAg | / | / | / | / | / | 281.60 | |||
HBsAb | / | / | / | / | / | - | |||
HBeAg | / | / | / | / | / | - | |||
HBeAb | / | / | / | / | / | + | |||
HBcAb | / | / | / | / | / | + | |||
98-2 | serum HBV DNA | - | 3.10 × 104 | 7.10 × 104 | 4.01 × 102 | 2.81 × 104 | 9.48 × 102 | ||
liver HBV DNA | 3.50 × 106 | 1.00 × 107 | 2.30 × 107 | 2.36 × 107 | 4.26 × 106 | 1.53 × 107 | |||
HBsAg | / | / | / | / | / | 380.00 | |||
HBsAb | / | / | / | / | / | - | |||
HBeAg | / | / | / | / | / | + | |||
HBeAb | / | / | / | / | / | - | |||
HBcAb | / | / | / | / | / | + | |||
121-1 | serum HBV DNA | 8.74 × 102 | 3.04 × 102 | 1.24 × 103 | 9.8 × 103 | 7.37 × 101 | 4.99 × 105 | ||
liver HBV DNA | 1.61 × 104 | 6.88 × 107 | 8.13 × 108 | 2.50 × 107 | 5.37 × 106 | 2.68 × 108 | |||
HBsAg | 0.14 | 111.97 | 424.00 | 334.12 | 260.92 | 380.99 | |||
HBsAb | - | - | - | - | - | - | |||
HBeAg | - | + | + | + | - | + | |||
HBeAb | - | - | - | - | - | - | |||
HBcAb | - | - | + | + | + | + | |||
122-1 | serum HBV DNA | 1.11 × 103 | - | - | 9.68 × 102 | 2.06 × 102 | 3.73 × 105 | ||
liver HBV DNA | 3.05 × 104 | 7.12 × 103 | 1.27 × 104 | 3.23 × 104 | 1.10 × 107 | 1.82 × 108 | |||
HBsAg | 0.18 | - | - | - | 3.78 | - | |||
HBsAb | + | ± | ± | - | - | - | |||
HBeAg | - | - | - | - | - | - | |||
HBeAb | - | - | - | - | - | - | |||
HBcAb | - | - | - | - | - | - | |||
123-3 | serum HBV DNA | - | 1.29 × 103 | - | 8.46 × 102 | 3.63 × 103 | 6.56 × 105 | ||
liver HBV DNA | 6.36 × 104 | 3.07 × 104 | 4.19 × 104 | 1.12 × 105 | 1.92 × 108 | 1.16 × 108 | |||
HBsAg | ± | 11.47 | 3.47 | + | + | 395.43 | |||
HBsAb | - | - | - | - | - | - | |||
HBeAg | ± | - | - | - | - | + | |||
HBeAb | - | - | - | - | - | - | |||
HBcAb | - | - | - | - | + | ||||