Clinical, epidemiological and molecular features of the HIV-1 subtype C and recombinant forms that are circulating in the city of São Paulo, Brazil

Alcalde, Rosana; Guimarães, Monick L; Duarte, Alberto JS; Casseb, Jorge

doi:10.1186/1743-422X-9-156

Virology Journal

Table 1 Epidemiological, virological, immunological characteristics and resistance associated mutations of PR/RT region from patients classified as HIV-1

From: Clinical, epidemiological and molecular features of the HIV-1 subtype C and recombinant forms that are circulating in the city of São Paulo, Brazil

I.D. LIM56	Date collection	Age (years)	Gender	VL	CD4	Transmission mode	Mutations Protease minor	Mutations other (Protease)	Mutations (NRTI)	Mutations (NNRTI)	Mutations other (RT)
A- subtype C
01	22/09/2003	48	M	248000	163	heterosexual	M36I, V82I, I93L	E35D, N37K, R41N, H69K, L89M	None	None	V35T, E36AE, T39E, S48T, K122E, I135T, K166R, F171Y, K173A, Q174K, D177E, I202V, Q207E, R211K, F214L, V245Q
02	25/09/2003	63	M	20500	254	heterosexual	L10I, M36T, I93L	T12P, K14R, I15V, L19I, N37K, R41N, H69K, L89M	None	None	V35T, E36A, T39D, S48T, V60I, K122E, K173A, D177E, T200V, Q207E, R211K
03	18/04/2005	31	M	62900	677	bisexual	M36I, L63P, I93L	T12A, N37K, R41N, H69K, L89M	None	None	V35T, E36A, T39E, K43R, S48T, K122E, D123S, I135T, K173A, D177E, Q207E, R211K, F214L
04	23/05/2005	22	M	17400	528	heterosexual	M36I, I93L	R41K, H69K, L89M	None	None	V35T, E36A, T39E, S48T, V60I, K64R, K122E, D123N, I135T, A158S, K173A, D177Q, Q207E, R211K
05	11/08/2005	37	F	>500000	54	heterosexual	M36I, L63P, I93L	T12A, I15V, L19I, E21EQ, N37K, R41N, H69K	None	None	V35T, T39E, S48T, I135T, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L
06	13/09/2005	37	M	24300	332	heterosexual	M36I, L63P, I93L	N37K, R41N, H69K, L89M	None	None	V35T, E36AE, T39D, K43R, S48T, K122E, D123N, K173A, D177E,V179I, G196E,T200A, E204K, Q207E, R211K
07	10/04/2006	39	F	30500	252	heterosexual	L10V, L63P, I93L	T12AT, I15V, N37K, R41N, H69K	None	None	V35T, E36A, T39D, S48T, K173A, T200A, E204D, Q207AE, R211K
08	11/05/2006	44	M	122000	106	heterosexual	M36I, I93L	I15V, R41K, H69K, T74A, L89M	None	None	K32R, V35T, E36A, T39D, S48T, K173A, Q174K, D177E, I178V, V179I, T200A, Q207E, R211K
09	03/08/2006	23	F	51100	278	heterosexual	M36I, I93L	I13V, I15V, L19I, N37K, R41N, H69K, T74S, L89M	None	K103R, V179D	E28K, K32E, V35T, E36A, T39D, S48T, V60I, S68G, V90I, K122E, D123N, I135T, K173A, D177E, T200A, E203D, Q207A, R211K
10	09/04/2007	25	M	67430	388	homosexual	None	M36T, N37K, R41N, L63P, H69K, L89M, I93L	None	None	V10X, V35T, E36A, T39D, K43R, D121H, K122E, D123S, K173A, D177E, Q197K, Q207K, R211K
11	4/5/2009	30	F	116623	881	heterossexual	L10I	E35D, M36I, N37K, R41N, K45R, D60E, L63Q, H69K, L89M, I93L	None	None	K11R, V35T, E36A, T39D, S48T, K122E, D123N, I135T, K173A, D177E, T200A, E204K, Q207E
12	4/5/2009	29	M	63980	71	heterossexual	None	T12P, I15V, E35D, M36I, N37K, R41N, K45R, D60E, L63Q, H69K, L89M, I93L	None	None	V35T, E36A, T39D, K43KR, S48T, K122E, D123N, I135T, K173A, D177E, T200A, E204K, Q207E, V245Q
13	8/4/2010	31	M	40.557	583	heterossexual	None	I15V, M36I, N37K, R41N, Q61N, L63T, H69K, L89M, I93L	None	K103N	V35T, T39EK, K173A, Q174R, T200A, Q207E, R211K
14	19/4/2010	42	M	59.024	176	heterossexual	T74S	I15V, M36T, N37K, R41N, K45R, L63T, H69K, I72IV, L89IM, I93L	None	None	V35T, E36A, T39E, A158S, K173A, T200A, Q207E, V245Q
15	5/5/2010	47	M	147.776	486	heterossexual	None	T12S, I15IV, L19I, T26AT, M36I, R41K, L63V, H69K	None	None	V35T, E36A, T39E, E40D, K122E, D123S, I135T, S162C, K173A, D177E, T200A, Q207E, R211K, V245Q, E248N
16	6/5/2010	26	F	3.024	289	heterossexual	None	T12S, I15V, L19I, E35D, M36L, N37K, R41N, L63P, H69K, V82I, L89M, I93L	V118I	None	V35T, E36A, T39E, D121H, K122E, D123S, I135T, T165IT, K173T, D177E, I178V, T200A, Q207E, R211K, F214L
B- subtype BC
17	08/03/2005	43	M	5880	353	heterosexual	L63P	I13V, K14R, E35D, I62V, I72V	G333A	None	V35T, E36A, T39D, S48ST, V60IV, K122E, D123S, R211K, V245Q, A272P, I293V, T296S, K311R
18	29/09/2005	40	M	14400	407	heterosexual	L63P	I13V, E35D, I64L, I72V	None	V179D	K22R, V35T, E36A, T39D, S48T, D121H, K122E, D123S, S162C, R211K, V245Q
19	09/01/2006	27	F	96300	345	heterosexual	L63P	I13V, E35D, I64L, I72V	None	V179D	K22R, V35T, E36A, T39D, S48T, D121H, K122E, D123S, R211K, V245Q
20	24/05/2007	42	M	111001	N/C	heterosexual	None	L5F, I13V, L19V, E35D, L63P, I72V, V77I	None	M230W	V35T, E36A, T39D, S48T, K122E, D123S, T165I, R211K, Y232F
21	26/06/2008	44	F	65477	N/C	Others	None	M36I, N37K, R41N, D60E, I62V, L63P, H69K, I93L	M41L, M184V, T215F	K103S, G190A	E28K, K32E, V35T, T39N, V60I, K101Q, K122E, D123N, T200A, V245Q
22	26/4/2010	56	M	38550	250	heterosexual	None	I13V, E35D, L63P, I72V	None	None	V35T, E36A, T39D, S48T, V60I, K122E, D123S, R211K, V245Q

Notes: M: Male; F: Female; VL: RNA HIV viral load; CD4: CD4 T cell count; N/C: data not collected; None: no mutation was found.

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ISSN: 1743-422X

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