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Table 2 Mutated amino acid sites of the deduced HA protein of the 10 viruses

From: The antigenic property of the H5N1 avian influenza viruses isolated in central China

sites

zfe

dw

xfy

xfj

ewhc

hm

d16

xn

zg

xga)

noteb)

21

E

E

V c)

E

E

E

E

E

E

E

Pattern 1

114

I

I

V

I

I

I

I

I

I

I

119

K

K

R

K

K

K

K

K

K

K

188

T

T

I

T

T

T

T

T

T

T

189

R

R

K

R

R

R

K

R

R

R

282

M

M

V

M

M

I

I

M

M

M

320

S

S

A

S

S

S

S

S

S

S

325

R

R

G

R

R

R

R

R

R

R

418

F

F

S

F

F

F

F

F

F

F

450

D

D

E

D

D

D

D

D

D

D

483

R

R

K

R

R

R

R

R

R

R

499

K

K

N

K

K

K

K

K

K

K

511

I

I

M

I

I

I

M

I

I

I

513

T

T

I

T

T

T

T

T

T

T

2

Q

Q

Q

Q

Q

Q

Q

H

H

H

Pattern 2

40

K

K

K

K

K

K

K

R

R

R

45

D

D

D

D

D

D

D

N

N

N

53

R

R

K

R

R

R

R

K

K

K

120

S

S

S

S

S

S

S

D

D

D

129

S

S

S

S

S

S

S

L

L

L

154

N

N

N

N

N

N

N

D

D

D

156

T

T

T

T

T

T

T

A

A

A

162

R

R

R

R

R

R

R

K

K

K

184

A

A

A

A

A

A

A

E

E

E

200

V

V

V

V

V

V

V

I

I

I

226

M

M

M

M

T

M

M

I

I

I

263

A

A

A

A

A

A

A

T

T

T

277

K

K

K

K

K

K

K

R

R

R

528

A

A

A

A

A

A

A

V

V

V

533

V

V

V

V

V

V

V

M

M

M

84

S

S

S

S

S

N

N

N

N

N

Pattern 3

94

D

D

D

D

D

N

N

N

N

N

124

N

N

N

N

N

D

D

D

G

D

138

L

L

L

L

L

Q

Q

Q

Q

Q

155

S

S

S

S

S

N

N

N

N

N

227

E

E

E

E

E

D

D

D

D

D

269

L

L

L

L

L

V

V

V

V

V

310

R

R

R

R

R

K

K

K

K

K

35

K

K

K

K

K

K

K

R

K

K

Pattern 4

139

G

R

G

G

G

G

G

G

G

G

140

K

K

R

K

K

T

T

N

N

N

141

S

S

P

S

S

P

P

S

S

S

151

I

I

I

I

I

I

I

I

I

T

161

K

K

K

K

K

R

K

K

K

K

174

V

V

V

V

V

I

I

V

V

V

181

P

P

P

P

P

S

S

P

P

P

209

L

F

L

L

L

L

L

L

L

L

240

N

D

N

N

N

N

N

N

N

N

313

L

L

L

L

L

P

L

L

L

L

322

Q

Q

Q

Q

Q

L

L

Q

Q

Q

354

Y

Y

Y

Y

Y

Y

F

Y

Y

Y

366

A

A

A

T

A

A

A

A

A

A

467

C

C

C

C

C

R

C

C

C

C

  1. Note:
  2. a): abbreviations of the 10 viruses: zfe/04, dw/04, xfy/04, xfj/04, ewhc/04, hm/06, d16/06, xn/07, zg/07 and xg/07.
  3. b): the four patterns mutated amino acids according to mutated situation showed in the text.
  4. c): residues in bold plus italic plus underline were mainly pattern 1 mutation happened in virus xfy/04; residues in bold plus italic were mainly pattern 2 and 3 mutations happened in viruses isolated in 2006–2007; residues in italic were sporadic mutations in the 10 viruses.