Figure 1From: Compensatory substitutions in the HCV NS3/4A protease cleavage sites are not observed in patients treated unsuccessfully with telaprevir combination treatmentBaseline conservation of cleavage sites. Sequence logos (Schnieder ref[18], Crooks ref[19]) were generated from baseline (pre-treatment) HCV sequence. Dashed lines indicate cleavage points along the HCV polyprotein, with the amino acid numbering below the cleavage site referencing HCV genotype 1a reference strain H77 (Genbank accession NC_004102). Cartoons of proteins are not drawn to scale. (Sample size for each sequence logo— NS3-NS4A and NS4A-NS4B: 1a = 327 patients, 1b = 242 patients; NS4B-NS5A and NS5A-NS5B: 1a = 219 patients, 1b = 108 patients).Back to article page