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Figure 1 | Virology Journal

Figure 1

From: Compensatory substitutions in the HCV NS3/4A protease cleavage sites are not observed in patients treated unsuccessfully with telaprevir combination treatment

Figure 1

Baseline conservation of cleavage sites. Sequence logos (Schnieder ref[18], Crooks ref[19]) were generated from baseline (pre-treatment) HCV sequence. Dashed lines indicate cleavage points along the HCV polyprotein, with the amino acid numbering below the cleavage site referencing HCV genotype 1a reference strain H77 (Genbank accession NC_004102). Cartoons of proteins are not drawn to scale. (Sample size for each sequence logo— NS3-NS4A and NS4A-NS4B: 1a = 327 patients, 1b = 242 patients; NS4B-NS5A and NS5A-NS5B: 1a = 219 patients, 1b = 108 patients).

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