Figure 5
Survival of mice passively immunized with anti-NS1 monoclonal antibodies. Groups of four-week-old C3H mice were administered with 100 μg (black dot) or 500 μg (white dot) of purified MAbs 3E10 (A), 4C4 (B), 7C2 (C), 7H5 (D), 8F1 (E) before being challenged with 20 pfu of SA14. Another group of mice received 100 μg of HIV anti-envelope MAb (black triangle) as a negative control. JEV-infected mice were monitored daily for 28 days post-challenge. Survival curves were constructed using data from one or two experiments with 6–12 mice in each group. χ2 values were obtained using a log-rank test by comparing the survival curve of each group with the anti-HIV group.