A single cidofovir treatment rescues animals at progressive stages of lethal orthopoxvirus disease

Table 1 Single dose of cidofovir is efficacious in treatment of lethal ECTV infection in a dose and time dependent manner

^a A single dose of cidofovir was given at days 1–7 post intranasal challenge with ECTV. 29 out of the 30 control infected untreated mice used in this experiments succumbed to infection.
^b The numbers indicate percent survival in each group. The number of animals in each group is indicated in parentheses. A minimum of 6 animals were used in each group. Large groups contained 12 animals (2 experiments of 6 animals), 22 animals (2 experiments of 6 animals plus additional experiment with 10 animals) and 28 animals (3 experiments of 6 animals plus additional experiment with 10 animals). N.D. – not done.
* Indicates for statistical significance compared to the control infected untreated group that was used in the same experiments (Fisher's Exact test, P < 0.05).

ISSN: 1743-422X