Figure 5

Single CDV treatment in conjunction with VACV vaccination does not impair the development of a “clinical take”. Mice were treated with CDV at concentrations of 5, 25 or 100 mg/kg 4 hours (day 0) or 24 hours (day 1) prior to vaccination with VACV-Lister. Vaccination was conducted by tail scarification on the base of the tail with 1X10⁶ pfu. Animals` "clinical take" was examined at day 13. Mice treated 4 hours prior to vaccination with 5 mg/kg (A-C), 25 mg/kg (D-F), 100 mg/kg (G-I). Mice treated with 100 mg/kg CDV 24 hours prior to vaccination (J-L) and control animals vaccinated without CDV treatment (M-O). Each group contained 6 mice from which 3 representatives are shown. Note that animal from plate I was the only one with the low score of 1.