Figure 4
From: A single cidofovir treatment rescues animals at progressive stages of lethal orthopoxvirus disease
CDV drug treatment reduced the viral titers in various organs following ECTV infection. Mice were infected with 20 pfu i.n. (= 20 LD50) and treated with 2.5 or 100 mg/kg CDV 24 hours later. Viral titers were evaluated in lungs on days 1 and 2 p.e. (A) and on day 8 p.e. in lungs (B), liver (C), spleen (D) and blood (E). Dotted line indicates the limit of detection. * Indicates for statistical significance compared to the control unprotected without CDV treatment (Mann–Whitney U-test, P < 0.05).