Figure 3

Cross-reactivity reduced vaccine increases survival from ADE in vivo. Survival of AG129 mice passively transferred 100 or 50 μL of pooled WT or RDERR immune sera from homologous ADE with 4.2 × 10⁴ ffu of DENV-2 S221. Kaplan-Meyer survival analysis (n = 10). p < 0.008 were considered significant due to Bonferonni adjusted alpha for multiple comparisons; three asterisk p < 0.0001.