Figure 2

Cross-reactivity reduced vaccines have reduced potential to participate in ADE in vitro compared to WT vaccine. (A) DENV-2 16681 enhancement reported as percent infection compared to the virus input control (dashed line) (B) DENV-1 56BC94/95 percent infection. (C) DENV-3 116RC1396 percent infection. (D) DENV-4 H241 percent infection. All data represent the mean+/−s.e.m. of two independent experiments. Two-way ANOVA were performed on square-root transformed data with a Bonfferoni post test; p < 0.05 were considered significant; single asterisk, p < 0.05; two asterisks, p < 0.01.