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Figure 4 | Virology Journal

Figure 4

From: MicroRNAs and hepatitis C virus: Toward the end of miR-122 supremacy

Figure 4

miR-29 and hepatitis C virus infection. miR-29 inhibits hepatitis C virus (HCV) replication in hepatocytes, maybe via cyclooxygenase-2 (COX-2) and IFN lambda (IFNλ), while at the same time HCV also inhibits miR-29 expression in hepatocytes to increase its replication. In hepatic stellate cells, miR-29 regulates the synthesis of the extracellular matrix (ECM), thus it inhibits fibrosis. HCV infection increases injury-associated TGFβ production, which inhibits miR-29 expression in stellate cells. This deregulates ECM synthesis and leads to fibrosis

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