Figure 5From: The HIV-1 Nef Protein Interacts with two components of the 40S small ribosomal subunit, the RPS10 protein and the 18S rRNA This scheme presents our hypothesis concerning the putative impact of Nef on ribosome biogenesis and on the translational process. The HIV-1 Nef protein binds to RPS10 and to 18S rRNA that could result in at least two distinct features: inhibition of ribosome biogenesis and direct inhibition of the translational process. ETS, external transcribed spacer; ITS, internal transcribed spacers 1 and 2; translation initiation factor eIF3.Back to article page