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Table 4 Molecular signatures derived on amino acid residue variations in chikungunya whole E1 proteins are shown below

From: Genetic characterization of Chikungunya virus from New Delhi reveal emergence of a new molecular signature in Indian isolates

Collection Year Sample   E1 protein: Amino Acid Residue Position
72 98 142 145 162 211 225 226 269 276 284 296 315 322
1966/2005 Africa S A I A V K A A I/V I D V V A
1953 ECSA N A I T I K A A M M D L V A/V
1985/2007 Asia S T I/V A/S I E S A M M D L V A
2010 Delhi N A I T I E A A V M E L V A
1963 West Bengal S T V S I E S A M M D L A A
2003/2006 Maharashtra N/S A/T I/V T/S I K/E A/S A V/M M E/D L V/A A
2006 Gujarat N A I T I K/N A A V M E L V A
2006 Puducherry N A I T I K/E A A V M E L V A
2006/2007/2008 Kerala N A I T I K A A/V V M E L V A
2007 Uttar Pradesh N A I T I K A A V M E L V A
2006/2008 Karnataka - A I T I K A A/V V M E L V A
2008/2009 Andhra Pradesh N A I T I K/N A A V M E L V A
  1. Amino acid residue positions of the complete E1 proteins, the Country/State and year of collection of CHIKV are denoted. (−) denotes sequence information not available.