Toll-like receptor pre-stimulation protects mice against lethal infection with highly pathogenic influenza viruses

Table 3 Antiviral effect of prestimulation by Toll-like receptor-specific ligands.

TLR stimulation	Virus strain	Ratio of MLD₅₀(log₁₀EID₅₀) between LPS-pretreated and mock-treated mice
TLR2 ^a	A/Vietnam/1203/04	0
TLR4 ^b	A/Vietnam/1203/04	1.0
TLR2	Sp HA/WSN ^c	0.76
TLR4	Sp HA/WSN ^c	0.49

^aSynthetic mycoplasmal lipoprotein (FSL-1)
^bLPS of E. coli K12 msbB (LPS agonist)
^cReassortant possessing the HA segment from influenza A/South Carolina/1918 (H1N1) and the remaining seven viral RNA segments from A/WSN/33 (H1N1).

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