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Table 4 Down regulated genes expressed in brain after JEV infection.

From: Transcriptomic profile of host response in Japanese encephalitis virus infection

Biological process

Gene Symbol

Accession No

Description

Fold change over mock-infected

    

1 DPI

2 DPI

4 DPI

5 DPI

Defense response

H2-Q1

U96752

Major histocompability complex Q1b

-1.56

-2.45

-4.46

-4.35

Endopeptidase

Inhibitor

Pbp2

NM_029595

Phosphatidylethanolamine binding protein 2

-2.67

-4.40

-1.91

-4.28

Cell cycle

Bmpr2

NM_007561

Bone morphogenic protein receptor

-3.94

-4.10

-3.91

-4.02

Oxidative stress

Epx

NM_007946

Eosinophil peroxidase

-1.05

1.05

-1.81

-3.75

Vasoconstriction

Avp

NM_009732

Arginine vasopressin

-3.09

3.04

-2.71

-3.57

T cell mediated cytotoxicity

Ptprc

AK088215

Protein tyrosine phosphatase, receptor type, C

-0.58

-0.55

-0.62

-3.35

Inflammatory response

Ccl24

NM_019577

Chemokine (C-C motif) ligand 24

-1.83

0.39

-0.08

-3.13

Leukotriene metabolic process

Ltc4

NM_008521

Mus musculus leukotriene C4 synthase

-0.30

0.37

-0.10

-3.01

Transcription

Rorb

AK044421

RAR-related orphan receptor beta

0.88

0.91

0.83

-2.91

Endocytosis

Mrc1

NM_008625

Mannose receptor, C type 1

-1.34

-0.42

-1.41

-2.81

Signal transduction

Calcr

NM_007588

Calcitonin receptor

-3.72

0.03

-2.71

-2.80

Leukotriene metabolic process

Alox12

NM_007440

Arachidonate 12-lipoxygenase

-0.73

0.35

-0.10

-2.72

NC

Msr2

NM_030707

Macrophage scavenger receptor 2

0.29

0.33

0.44

-2.59

Transport

Trpa1

NM_177781

Transient receptor potential cation channel

0.11

-2.00

-0.19

-2.52

Microtubule-based process

Kif1b

NM_207682

Kinesin family member 1B

-0.92

-1.69

-2.30

-2.48

Immune response

Cxcl4

NM_019932

Chemokine (C-X-C motif) ligand 4

-0.61

0.06

-0.52

-2.33

Translation

Eif2s3x

NM_012010

Eukaryotic translation initiation factor

-0.28

-2.47

-2.29

-2.27

Transcription

Zfp101

NM_009542

Zinc finger protein 101

-0.48

-0.36

-2.10

-2.20

Transcription

Irx6

NM_022428

Iroquois related homeobox 6

-1.12

-0.58

-1.20

-2.19

Prostaglandin biosynthesis

Ptgis

NM_008968

Prostaglandin I2

-0.67

-0.46

-1.19

-2.19

MAPK activity

Prok2

NM_015768

Prokineticin 2

-1.67

-0.53

-1.76

-2.13

Cell adhesion

Pcdh12

NM_017378

Protocadherin 12

-0.17

-0.27

-0.68

-2.10

Apoptosis

Ngfr

NM_033217

Nerve growth factor receptor

-1.74

0.32

-1.73

-2.00

  1. NC Not classified
  2. Genes were considered significantly upregulated or downregulated if the change in their relative expression levels was ≥ 2 fold or ≤ -2 fold, respectively.