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Table 4 Differentially-regulated genes of our interest in brains of mice with JEV Infection.

From: Japanese encephalitis virus infection induces changes of mRNA profile of mouse spleen and brain

Genbank Accession

Gene symbol

Gene description

Fold change

p-Value

Up-regulated

    

NM_021274

Cxcl10

chemokine (C-X-C motif) ligand 10

1760.024

0.0020

NM_011333

Ccl2

chemokine (C-C motif) ligand 2

1387.794

0.0320

NM_013652

Ccl4

chemokine (C-C motif) ligand 4

336.804

0.0151

NM_010846

Mx1

myxovirus (influenza virus) resistance 1

229.188

0.0136

NM_145209

Oasl1

2'-5' oligoadenylate synthetase-like 1

209.863

0.0242

NM_011940

Ifi202b

interferon activated gene 202B

201.477

0.0317

NM_008329

Ifi204

interferon activated gene 204

165.395

0.0404

NM_021792

Iigp1

interferon inducible GTPase 1

159.817

0.0168

NM_011337

Ccl3

chemokine (C-C motif) ligand 3

111.943

0.0429

NM_008176

Cxcl1

chemokine (C-X-C motif) ligand 1

107.659

0.0158

AK085407

Ifi44

interferon gamma inducible protein 44

91.009

0.0062

NM_010555

Il1r2

interleukin 1 receptor, type II

89.273

0.0297

NM_021893

Cd274

CD274 antigen

87.250

0.0337

NM_008330

Ifi47

interferon gamma inducible protein 47

83.552

0.0286

NM_172648

Ifi205

interferon activated gene 205

82.479

0.0416

NM_194336

Mpa2l

macrophage activation 2 like

77.279

0.0464

NM_007609

Casp4

caspase 4, apoptosis-related cysteine peptidase

77.077

0.0451

NM_017466

Ccrl2

chemokine (C-C motif) receptor-like 2

74.783

0.0071

NM_008332

Ifit2

interferon-induced protein with tetratricopeptide repeats 2

65.247

0.0222

NM_011331

Ccl12

chemokine (C-C motif) ligand 12

65.192

0.0079

NM_033601

Bcl3

B-cell leukemia/lymphoma 3

53.003

0.0138

NM_029803

Ifi27

interferon, alpha-inducible protein 27

47.264

0.0403

NM_031168

Il6

interleukin 6

44.884

0.0106

NM_016850

Irf7

interferon regulatory factor 7

42.752

0.0463

NM_145211

Oas1a

2'-5' oligoadenylate synthetase 1A

41.831

0.0497

NM_011909

Usp18

ubiquitin specific peptidase 18

40.804

0.0052

NM_010501

Ifit3

interferon-induced protein with tetratricopeptide repeats 3

39.282

0.0008

NM_007707

Socs3

suppressor of cytokine signaling 3

36.912

0.0087

NM_008331

Ifit1

interferon-induced protein with tetratricopeptide repeats 1

32.115

0.0013

NM_013606

Mx2

myxovirus (influenza virus) resistance 2

31.018

0.0003

NM_011854

Oasl2

2'-5' oligoadenylate synthetase-like 2

29.655

0.0131

NM_009896

Socs1

suppressor of cytokine signaling 1

28.609

0.0492

NM_009140

Cxcl2

chemokine (C-X-C motif) ligand 2

24.678

0.0392

NM_010397

H2-T22

histocompatibility 2, T region locus 22

21.010

0.0473

NM_027835

Ifih1

interferon induced with helicase C domain 1

19.804

0.0233

NM_009397

Tnfaip3

tumor necrosis factor, alpha-induced protein 3

19.385

0.0300

NM_009283

Stat1

signal transducer and activator of transcription 1

18.134

0.0348

NM_001083925

Oas1b

2'-5' oligoadenylate synthetase 1B

17.574

0.0342

NM_008361

Il1b

interleukin 1 beta

15.753

0.0043

NM_133211

Tlr7

toll-like receptor 7

9.880

0.0343

NM_027450

Glipr2

GLI pathogenesis-related 2

9.275

0.0405

NM_008562

Mcl1

myeloid cell leukemia sequence 1

9.054

0.0336

NM_029419

Apol3

apolipoprotein L 3

8.806

0.0165

NM_001008700

Il4ra

interleukin 4 receptor, alpha

8.639

0.0360

NM_013730

Slamf1

signaling lymphocytic activation molecule family member 1

8.274

0.0435

NM_009841

Cd14

CD14 antigen

6.666

0.0034

NM_033541

Oas1c

2'-5' oligoadenylate synthetase 1C

6.596

0.0120

NM_009810

Casp3

caspase 3, apoptosis-related cysteine peptidase

2.119

0.0117

Down-regulated

    

NM_053094

Cd163

CD163 antigen

0.066

0.0007

XM_898059

Cd209f

CD209f antigen

0.088

0.0271

NM_026972

Cd209b

CD209b antigen

0.132

0.0149

NM_033042

Tnfrsf25

tumor necrosis factor receptor superfamily, member 25

0.196

0.0288

NM_016708

Npy5r

neuropeptide Y receptor Y5 (Npy5r)

0.242

0.0351

NM_019577

Ccl24

chemokine (C-C motif) ligand 24 (Ccl24)

0.302

0.0132

NM_008409

Itm2a

integral membrane protein 2A

0.302

0.0075

AK042749

D230046B21Rik

7 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:A730020N04

0.311

0.0358

NM_030143

Ddit4l

DNA-damage-inducible transcript 4-like

0.318

0.0004

NM_022723

Scube1

signal peptide, CUB domain, EGF-like 1

0.319

0.0400

AK144387

4732444A12Rik

21 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:G630051C23

0.319

0.0000

AK082652

Tmem44

transmembrane protein 44

0.324

0.0108

NM_175106

Tmem177

transmembrane protein 177 (Tmem177)

0.330

0.0346

NM_175564

Tmem169

transmembrane protein 169

0.336

0.0371

NM_027016

Tloc1

translocation protein 1

0.336

0.0276

NM_027163

Il1f8

interleukin 1 family, member 8

0.421

0.0267

NM_022986

Irak1bp1

interleukin-1 receptor-associated kinase 1 binding protein 1

0.422

0.0169

NM_016851

Irf6

interferon regulatory factor 6

0.447

0.0303

NM_145826

Il17re

interleukin 17 receptor E (Il17re), transcript variant 1

0.477

0.0403