Table 3 Differentially-regulated genes of our interest in spleens of mice with JEV Infection

Up-regulated

NM_177261

Kndc1

kinase non-catalytic C-lobe domain (KIND) containing 1

21.440

0.0252

NM_019494

Cxcl11

chemokine (C-X-C motif) ligand 11

19.752

0.0084

NM_013542

Gzmb

granzyme B

6.202

0.0286

NM_031167

Il1rn

interleukin 1 receptor antagonist (Il1rn), transcript variant 1

6.060

0.0015

AK157531

LOC629091

activated spleen cDNA, RIKEN full-length enriched library, clone:F830221E13

5.500

0.0154

NM_001033228

Itga1

integrin alpha 1

5.482

0.0308

NM_013584

Lifr

leukemia inhibitory factor receptor

5.319

0.0109

NM_177923

H2-M10.2

histocompatibility 2, M region locus 10.2

5.276

0.0009

NM_008198

Cfb

complement factor B

5.188

0.0019

NM_001005858

LOC667370

similar to interferon-induced protein with tetratricopeptide repeats 3

4.949

0.0459

NM_145153

Oas1f

2'-5' oligoadenylate synthetase 1F

4.619

0.0013

NM_011331

Ccl12

chemokine (C-C motif) ligand 12

4.539

0.0308

NM_027893

Pvrl4

poliovirus receptor-related 4

4.429

0.0352

NM_010741

Ly6c

lymphocyte antigen 6 complex, locus C

4.287

0.0042

NM_010370

Gzma

granzyme A

4.236

0.0010

NM_009152

Sema3a

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

4.132

0.0358

AF229257

Usp29

ubiquitin-specific processing protease 29

4.033

0.0093

NM_133871

Ifi44

interferon-induced protein 44

3.843

0.0053

NM_009912

Ccr1

chemokine (C-C motif) receptor 1

3.734

0.0013

BC025535

Fcgr1

Fc receptor, IgG, high affinity I

3.668

0.0096

NM_145226

Oas3

2'-5' oligoadenylate synthetase 3

3.531

0.0017

NM_008331

Ifit1

interferon-induced protein with tetratricopeptide repeats 1

3.433

0.0460

NM_021274

Cxcl10

chemokine (C-X-C motif) ligand 10

3.418

0.0307

NM_016850

Irf7

interferon regulatory factor 7

3.378

0.0083

NM_008530

Ly6f

lymphocyte antigen 6 complex, locus F

3.313

0.0027

NM_011940

Ifi202b

interferon activated gene 202B

3.296

0.0266

NM_145211

Oas1a

2'-5' oligoadenylate synthetase 1A

3.283

0.0082

NM_145227

Oas2

2'-5' oligoadenylate synthetase 2

3.178

0.0083

NM_144559

Fcgr4

Fc receptor, IgG, low affinity IV

3.069

0.0067

NM_027835

Ifih1

interferon induced with helicase C domain 1

2.940

0.0258

NM_008462

Klra2

killer cell lectin-like receptor, subfamily A, member 2

2.906

0.0001

NM_021792

Iigp1

interferon inducible GTPase 1

2.535

0.0232

L38281

Irg1

immune-responsive gene 1

2.496

0.0329

NM_008329

Ifi204

interferon activated gene 204

2.422

0.0290

NM_025378

Ifitm3

interferon induced transmembrane protein 3

2.401

0.0002

NM_021378

Klrc3

killer cell lectin-like receptor subfamily C, member 3

2.396

0.0063

NM_011909

Usp18

ubiquitin specific peptidase 18

2.333

0.0473

NM_011333

Ccl2

chemokine (C-C motif) ligand 2

2.314

0.0356

NM_028968

Ifitm7

interferon induced transmembrane protein 7

2.246

0.0014

NM_008337

Ifng

interferon gamma

2.229

0.0054

NM_011338

Ccl9

chemokine (C-C motif) ligand 9

2.155

0.0065

NM_010653

Klrc2

killer cell lectin-like receptor subfamily C, member 2

2.131

0.0076

NM_009909

Il8rb

interleukin 8 receptor, beta

2.077

0.0036

NM_010555

Il1r2

interleukin 1 receptor, type II

2.069

0.0248

NM_010652

Klrc1

killer cell lectin-like receptor subfamily C, member 1

2.025

0.0125

NM_011073

Prf1

perforin 1 (pore forming protein)

1.820

0.0326

NM_010722

Lmnb2

lamin B2

1.381

0.1976

Down-regulated

NM_025989

Gp2

glycoprotein 2 (zymogen granule membrane)

0.048

0.0005

NM_053094

Cd163

CD163 antigen

0.060

0.0171

NM_177261

Kndc1

kinase non-catalytic C-lobe domain (KIND) containing 1

0.085

0.0070

NM_144943

Cd207

CD 207 antigen

0.159

0.0441

NM_010378

H2-Aa

histocompatibility 2, class II antigen A, alpha

0.184

0.0055

NM_028135

Tmem163

transmembrane protein 163

0.211

0.0196

NM_007720

Ccr8

chemokine (C-C motif) receptor 8

0.242

0.0150

NM_016851

Irf6

interferon regulatory factor 6

0.261

0.0037

NM_013509

Eno2

enolase 2, gamma neuronal (Eno2)

0.276

0.0234

NM_011780

Adam23

a disintegrin and metallopeptidase domain 23 (Adam23)

0.281

0.0009

U96752

H2-Q1

major histocompability complex Q1b

0.282

0.0247

NM_008341

Igfbp1

insulin-like growth factor binding protein 1

0.289

0.0144

NM_010565

Inhbc

inhibin beta-C (Inhbc)

0.304

0.0307

AK089361

AK089361

B6-derived CD11 +ve dendritic cells cDNA

0.307

0.0417

NM_013517

Fcer2a

Fc receptor, IgE, low affinity II, alpha polypeptide

0.315

0.0318

NM_016808

Usp2

ubiquitin specific peptidase 2 (Usp2), transcript variant 1

0.319

0.0266

AK041838

Il7r

interleukin 7 receptor

0.319

0.0256

NM_001033126

Cd27

CD antigen 27 (Cd27), transcript variant 1

0.326

0.0158

NM_009142

Cx3cl1

chemokine (C-X3-C motif) ligand 1

0.343

0.0227

NM_010215

Il4i1

interleukin 4 induced 1

0.387

0.0129

NM_207105

H2-Ab1

histocompatibility 2, class II antigen A, beta 1

0.520

0.0255

NM_033217

Ngfr

nerve growth factor receptor (TNFR superfamily, member 16)

0.440

0.0110

AK041345

Xlr4a

X-linked lymphocyte-regulated 4A

0.460

0.0074

NM_033042

Tnfrsf25

tumor necrosis factor receptor superfamily, member 25

0.465

0.0366

NM_198297

Trat1

T cell receptor associated transmembrane adaptor 1

0.476

0.0334

NM_011161

Mapk11

mitogen-activated protein kinase 11

0.478

0.0128

NM_007549

Blk

B lymphoid kinase

0.483

0.0103

NM_010818

Cd200

Cd200 antigen

0.494

0.0156