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Table 2 Summary of predicted tyrosine phosphorylation sites.

From: Envelope 2 protein phosphorylation sites S75 & 277 of hepatitis C virus genotype 1a and interferon resistance: A sequence alignment approach

Phosphorylation sites

Site*a

aa*b

Context*c

NetPhos*d

Scansite*e

NetSurfP*f

I-TASSER*g

75

S

ERLASCKPL

0.977

Y

E

Yes

95

S

YANGSGPEH

0.969

_

E

Yes

118

S

VPAQSVCGP

0.885

_

E

Yes

277

S

DRDRSELSP

0.978

Y

E

Yes

221

T

GPWITPRCL

0.951

Y

E

No

211

Y

PEATYSRCG

0.863

Y

B

Yes

  1. a. Phosphorylation sites in the local 1a sequence of the envelope gene.
  2. b. S indicates Serine; T is for Threonine and Y for Tyrosine predictions.
  3. c. Region where the phosphorylation sites are available.
  4. d. Predicted sites by NetPhos with a score of ≥ 0.8. Dashes indicate lack of Phosphorylation sites in that position.
  5. e. Y indicates predicted sites in sequence on "Low Stringency". Dashes indicate lack of Phosphorylation sites in that position.
  6. f. E indicates Exposed sites and B indicates Buried sites. Surface accessibility calculated by NetSurfP.
  7. g. Ab-initio 3D model was constructed by using I-TASSER server.