Cellular immune responses in patients with hepatitis B surface antigen seroclearance induced by antiviral therapy

Table 1 The HBV seromarkers, genotypes and mutations in patients with HBsAg seroclearance

Patient	Genotype	Drugs	HBsAg^a	HBsAb^a	HBeAg^a	HBeAb^a	HBcAb^a	Mutations in RT	Mutations in S
SC-1	UD	ETV	NEG	NEG	NEG	NEG	POS	UD	UD
SC-2	UD	LAM	NEG	NEG	NEG	POS	POS	UD	UD
SC-3	UD	ETV	NEG	POS	POS^b	NEG	POS	UD	UD
SC-4	UD	LAM	NEG	POS	NEG	POS	POS	UD	UD
SC-5	B	Peg-IFN	NEG	NEG	NEG	POS	POS	L199V	T47A, C48R, S61L, I68T, L109P, W196L, I208T
SC-6	C	Peg-IFN, ETV	NEG	POS	POS^b	NEG	POS	T54S, H55R P109Q	T47A, I68T Q101K, P111S, T123K, I126T, P203R
SC-7	C	LAM	NEG	NEG	NEG	NEG	POS	H55R, V56A; L80I, L180M, M204I	T47A, C48R, S61L, I68T, L109P, W196L
SC-8	UD	Peg-IFN, LAM	NEG	POS	NEG	POS	POS	UD	UD
SC-9	UD	Peg-IFN	NEG	POS	NEG	NEG	POS	UD	UD
SC-10	C	Peg-IFN, LAM	NEG	POS	NEG	NEG	POS	S53T, H55S Y124H, M129L	A45L, T47V, W199L, Y200F
SC-11	C	LAM	NEG	NEG	NEG	NEG	POS	Y124H, V207I	M198L, W199L, Y200F
SC-12	UD	Peg-IFN	NEG	POS	NEG	NEG	POS	UD	UD
SC-13	C	LAM	NEG	NEG	NEG	NEG	POS	H55R, V56A L80I, L180M, M204I	T47A, C48R, S61L, I68T L109P, W196L
SC-14	UD	LAM	NEG	POS	NEG	NEG	POS	UD	UD

Note. SC, patient with HBsAg seroclearance; UD, HBV DNA undetectable by nested PCR; ETV, entecavir; LAM, lamivudine; Peg-IFN, pegylated IFN; NEG, negative; POS, positive; RT, reverse transcriptase; S, S open reading frame; HBsAb, antibody to HBsAg; HBeAb, antibody to HBeAg; HBcAb, antibody to HBcAg.
^a HBV serum markers were all determined by chemiluminescent microparticle immunoassay through Abbott ARCHITECT^® i2000 system.
^b Two of these were seropositive for HBeAg at the time we collected the blood sample. However, both subjects became HBeAg-negative during follow-up.

ISSN: 1743-422X