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Table 3 Amino acid changes during consecutive passages of rgVac1 mutants

From: H9N2 influenza virus acquires intravenous pathogenicity on the introduction of a pair of di-basic amino acid residues at the cleavage site of the hemagglutinin and consecutive passages in chickens

Passage number

rgVac1sub (H5N1)

rgVac1ins (H5N1)

 

PA

HA

NP

M1

M2

 

HA

 

NA

M1

 

65a

672

308

338

213

374

89

101

45

157

298

465

171

130

P0

S

L

H

-

R

M

D

R

R

S

M

D

N

L

P1

.b

.

Q

Rc

.

.

.

.

H

P

.

E

.

.

P2

T

.

Q

R

.

.

.

K

H

P

.

.

.

.

P3

.

F

Q

R

Q

V

N

K

H

P

I

.

N/Hd

I

  1. a Methionine encoded by the AUG start codon is defined as position 1.
  2. b Periods indicate same amino acids as the parental virus.
  3. c Arginine was inserted at the HA cleavage site.
  4. d Amino acid quasispecies were observed.