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Figure 1 | Virology Journal

Figure 1

From: H9N2 influenza virus acquires intravenous pathogenicity on the introduction of a pair of di-basic amino acid residues at the cleavage site of the hemagglutinin and consecutive passages in chickens

Figure 1

Nucleotide and amino acid sequences at the HA cleavage site of each virus. (A) Mutations were introduced into the HA genes of rgY55 (H9N2) and rgVac1 (H5N1) strains to give multibasic amino acids at their cleavage sites by site-directed mutagenesis. Mutation sites were underlined and deduced amino acid sequences were depicted in italics. Basic amino acids were shown in bold. (B) Nucleotide and amino acid sequences at the HA cleavage site of rgVac1sub-P1 (H5N1). rgVac1sub (H5N1) acquired an additional argenine residue represented by the codon AGA after one passage in chickens.

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Virology Journal

ISSN: 1743-422X