Skip to main content
Figure 7 | Virology Journal

Figure 7

From: Rotavirus NSP4 is secreted from infected cells as an oligomeric lipoprotein and binds to glycosaminoglycans on the surface of non-infected cells

Figure 7

NSP4 binds to cells via glycosaminoglycan receptors. A, Binding of NSP4 to HT-29 cells treated with Heparinase I or III. B, Pre-treatment of CHO cells with sodium chlorate inhibits the binding of NSP4. Cells were incubated with various concentrations of chlorate for 24 h prior to suspension and addition to the binding assay. C. Inhibition of NSP4 binding by inclusion of soluble GAGs in the binding assay; CS-A; chondroitin sulphate A, CS-B; chondroitin sulphate B, HP; heparin, HS; heparan sulphate. D, Inhibition of NSP4 binding by Heparinase III treatment in different cell lines. Data shown are mean +/- SEM from at least three independent experiments

Back to article page