Epitope start Position | Predicted T-cell epitopes | HLA alleles | HCV genotype 1 | HCV Genotype 2 | HCV Genotype 3 |
---|---|---|---|---|---|
Capsid | Â | Â | Â | Â | Â |
38 | R RGPRLGVR | 9 | RRGPRLGVR | RRGPRLGVR | RRGPRLGVR |
35 | V LPRRGPRL | 25 | Â | Â | VLPRRGPRL |
Core | Â | Â | Â | Â | Â |
55 | P GCSFSIFL | 8 | PGCSFSIFL | PGCSFSIFL | PGCSFSIFL * |
41 | R ALEDGINF | 20 | Â | RV LEDGV NF ** | RALEDGINF * |
7 | V IDTLTCGF | 15 | VIDTLTCGF | VIDTI TCGF * | VIDTLTCGF * |
35 | A LAHGVRAL | 24 | ALAHGVRV L | ALAHGVRVL | ALAHGVRAL * |
24 | L VGAPVGGV | 18 | LVGAPL GGA * | Â | LVGAPVGGV * |
26 | G APVGGVAR | 9 | GAPL GGA AR * | GAPL GGVAR | GAPVGGVAR * |
E1 | Â | Â | Â | Â | Â |
135 | S PAVGMVVA | 14 | Â | Â | SPAM GMVVA * |
86 | G DVCGAVFL | 19 | GDL CGS VFLD | GDVCGAVMI | GDM CGAVFL * |
144 | H ILRLPQTL | 22 | Â | Â | HILRLPQTL * |
156 | I AGAHWGVL | 27 | IAGAHWGVL | Â | IAGAHWGI L |
64 | A SIRGHVDL | 25 | Â | Â | ASIRS HVDLD |
E2 | Â | Â | Â | Â | Â |
285 | P LLHSTTEL | 11 | Â | PLLHSTTEWD | PLLHSTTEL |
305 | A LSTGLIHL | 25 | ALT TGLIHL | Â | ALSTGLIHL |
227 | C SFTPMPA L | 20 | CSFTTL PALD * | Â | CSFTPMPAL |
71 | Q QLQAHHFL | 27 | Â | Â | Â |
157 | C GLLVVGGL | 28 | Â | Â | Â |
212 | R GHIQPVRL | 24 | Â | Â | Â |
6 | T AARGGQGL | 25 | Â | Â | Â |
157 | C GLLVVGGL | 28 | Â | Â | Â |
NS2 | Â | Â | Â | Â | Â |
172 | V ITWGADTA | 6 | Â | Â | VITWGADTA * |
75 | F DIAKLLIA | 12 | FDIT KLLL AD | FDIT KLLL AD * | FDIT KLLIAD |
70 | Y PSL VFDIA | 15 | Â | Â | YPSLI FDITDD |
57 | G SRDGVILL | 21 | GG RDA VILLD ** | GG RDA VILLD * | GSRDGVILL |
60 | D GVILLTSL | 26 | Â | Â | DGVILLTSL * |
148 | W AAAGLKDL | 27 | Â | WAAS GLR DLDD** | WAAAGLKDL * |
50 | V PPLLARGS | 11 | Â | Â | VPPLLARGS * |
46 | L QVWVPPLL | 28 | LH VWVPPLNDD | LH VWVPPLNDD * | LQVWVPPLL * |
117 | V TGGKYFQM | 16 | Â | Â | VV GGKYFQMD * |
65 | L TSLLYPSL | 23 | Â | Â | LTSLLYPSL |
6 | T LGAGILVL | 48 | Â | Â | TLGAGV LVL * |
73 | L VFDIAKLL | 31 | LVFDIT KLLD | LVFDIT KLLD * | LI FDIT KLLD |
145 | M QHW AAAGL | 26 | Â | Â | MQHWAAAGL |
178 | D TAACGDIL | 21 | DTAACGDII | DTAACGDIID * | DTAACGDIL |
NS3 | Â | Â | Â | Â | Â |
119 | G HVAGIFRA | 8 | GHAV GIFRA * | GHVV GL FRA * | Â |
27 | Y HGAGSRTL | 14 | YHGAGT RTI | YHGAGNK TLD | Â |
128 | A VCTRGVAK | 8 | AVCTRGVAK | AVCTRGVAK * | Â |
57 | P APPGAKSL | 11 | PAPQ GAR SLDD * | PS PPGT KSLDD | Â |
98 | L SPRPLACL | 25 | Â | LSPRPLST LD | Â |
95 | A SLL SPRPL | 24 | Â | Â | Â |
130 | C TRGVAKAL | 20 | CTRGVAKAV | Â | Â |
7 | L STATQTFL | 24 | Â | Â | Â |
NS4a | Â | Â | Â | Â | Â |
3 | W VL LGGVLA | 11 | WVLV GGVLA | WVLV GGVLA | WVLLGGVLA |
23 | V VIVGHIEL | 21 | VVIVGR II LDD | VVIVGR IV LDD | VVIVGHIEL |
10 | L AALAAYCL | 24 | LAALAAYCL * | LAALAAYCL | LAALAAYCL |
5 | L LGGVL AAL | 27 | LV GGVLAAL | LV GGVLAAL | LLGGVLAAL |
NS4b | Â | Â | Â | Â | Â |
96 | P QSSSAFVV | 6 | Â | Â | PQSSSAFVV |
40 | N FVSGIQ YL | 30 | NFI SGIQYL | NFI SGIQYL | NFVSGIQYL |
81 | F FNIL GGWV | 13 | Â | Â | FFNILGGWV |
46 | Q YLAGLSTL | 17 | QYLAGLSTL | QYLAGLSTL | QYLAGLSTL |
102 | FV VSGLAGA | 9 | Â | FVGA GLAGAD | FVVSGLAGA |
54 | L PG NPAVAS | 14 | LPGNPAI AS | LPGNPAI AS | LPGNPAVAS |
161 | S PGALVVGV | 14 | SPGALVVGV | SPGALVVGV | SPGALVVGV |
141 | I MGGELPNA | 7 | Â | Â | IMGGEF PT AD * |
164 | A LVVGVICA | 11 | ALVVGVV CA | ALVVGVV CA | ALVVGVICA |
117 | L GRVLLDIL | 22 | LGK VLV DILD* | LGK VLV DILD | LGK VLLDILD * |
59 | A VASLMAFA | 9 | AI ASLMAFTD | AI ASLMAFTD | AVASLMAFTD |
152 | V VNLLPAIL | 15 | Â | Â | Â |
113 | G IGLGRVLL | 24 | Â | Â | GIGLGK VLLD * |
56 | G NPAVASLM | 12 | GNPAI ASLM | GNPAI ASLM | GNPAVASLM |
52 | S TLPGNPAV | 21 | STLPGNPAI | STLPGNPAV | STLPGNPAV |
85 | L GGWVATHL | 26 | LGGWVAAQ LDD | LGGWVAAQ LDD | LGGWVATHL |
145 | E LPNAEDVV | 11 | Â | Â | Â |
99 | S SAFVVSGL | 22 | Â | Â | SSAFVVSGL |
NS5a_1a | Â | Â | Â | Â | Â |
33 | H VKNGSMRL | 16 | HVKNGSMRI * | HVKNGSMRI ** | HVKNGSMRL |
NS5a_1b | Â | Â | Â | Â | Â |
49 | V PAAEFFTE | 6 | VPAP EFFTE * | VPAP EFFTE ** | VPAAEFFTE |
79 | T FVVGLNSY | 10 | TFQ VGLNQ YD * | TFT VGLNSFD * | TFT VGLNSYD * |
76 | D EITFVVGL | 19 | DEV TFQ VGLD * | DEV TFT VGLD* | DEITFM VGL * |