Epitope start Position | Predicted T-cell epitopes | HLA alleles | HCV genotype 1 | HCV Genotype 2 | HCV Genotype 3 |
---|---|---|---|---|---|
Capsid | Â | Â | Â | Â | Â |
43 | L GVRATRKA | 23 | LGVRATRKTD | LGVRATRKT | LGVRATRKTD |
36 | L PRRGPRL G | 15 | LPRRGPRLG | LPRRGPRLG | LPRRGPRLG |
106 | W GPNDPRRR | 16 | WGPT DPRRR | WGPT DPRH RD | WGPNDPRRR |
34 | Y VLPRRGPR | 24 | YL LPRRGPR | YL LPRRGPR | YVLPRRGPR |
21 | V KFPGGGQI | 8 | VKFPGGGQI * | VKFPGGGQI | VKFPGGGQI |
35 | V LPRRGPRL | 9 | Â | Â | VLPRRGPRL |
45 | V RATRKASE | 25 | VRATRKT SED | VRATRKT SED | VRATRKT SED |
30 | V GGVY VLPR | 39 | VGGVYL LPR * | VGGVYL LPR | VGGVYVLPR |
15 | I RRPQDVKF | 6 | Â | Â | IRRPQDVKF |
95 | W LLSPRGSR | 28 | WLLSPRGSR | WLLSPRGSR | WLLSPRGSR |
29 | I VGGVYVLP | 3 | IVGGVYL LP * | IVGGVYL LP | IVGGVYVLP |
82 | W PLYGNEGC | 10 | WPLYGNEGC | WPLYGNEGC | WPLYGNEGC |
85 | Y GNEGCGWA | 11 | YGNEGCGWA | YGNEGCGWA * | YGNEGCGWA |
33 | V YVL PRRGP | 1 | VYL LPRRGP | VYL LPRRGP | VYVLPRRGP |
Core | Â | Â | Â | Â | Â |
61 | F LL ALLSCL | 50 | FLLALLSCL | FLLALLSCI | FLLALLSCL |
64 | L ALLSCLIH | 45 | LALLSCLTVDD | Â | LALLSCLIH * |
15 | F ADLMGYIP | 41 | FADLMGYIP | FADLMGYIP | FADLMGYIP |
24 | L VGAPVGGV | 44 | LVGAPL GGA | Â | LVGAPVGGV * |
63 | LL ALLSCLI | 36 | LLALLSCLTD | LLALLSCITD | LLALLSCLI * |
62 | FLL ALLSCL | 24 | FLLALLSCL | FLLALLSCI | FLLALLSCL * |
32 | V ARALAHGV | 10 | Â | VARALAHGV | VARALAHGV |
21 | Y IPLVGAPV | 28 | YIPLVGAPL | YIPV VGAPL | YIPLVGAPV |
19 | M GYIPLVGA | 26 | MGYIPLVGA | MGYIPV VGA | MGYIPLVGA |
E1 | Â | Â | Â | Â | Â |
58 | Y VGATTASI | 41 | Â | Â | YVGATTASI * |
140 | M VVAHILRL | 39 | Â | Â | MVVAHILRL* |
2 | W RNTSGLY V | 27 | Â | Â | WRNTSGLYV |
138 | V GM VVAHIL | 28 | Â | Â | Â |
56 | V KY VGATTA | 21 | Â | Â | VR YVGATTAD * |
9 | Y VLTNARSN | 31 | Â | Â | YVLTNDC SNDD |
161 | W GVLAGLAY | 15 | WGVLAGM AY | WGVVF GLAY | WGI LAGLAY |
93 | F LVGQAFTF | 11 | FLVGQL FTF | Â | FLVGQAFTF |
181 | I IMVMFSGV | 91 | Â | Â | IIMVMFSGV |
130 | M MMNWSPAV | 35 | MMMNWSPTAD | Â | MMMNWSPAM |
134 | W SPAV GM VV | 6 | Â | Â | WSPAM GMVV * |
132 | M NW SPAV GM | 14 | Â | Â | MNWSPAM GM * |
169 | Y YTM QGNWA | 18 | Â | Â | YYS MQGNWA |
47 | W TPMTPTVA | 21 | Â | Â | WTPV TPTVA * |
172 | M QGNWAKVA | 25 | MV GNWAKVLD | MQGA WAKVID | WTPV TPTVAD * |
145 | I LRLPQTLF | 19 | Â | Â | ILRLPQTLF |
E2 | Â | Â | Â | Â | Â |
122 | M LPHHRPVV | 3 | Â | Â | Â |
151 | V FLLNPCGL | 48 | Â | Â | Â |
337 | W EF VILVFL | 4 | Â | Â | WEFIV LVFL |
339 | F VIL VFLLL | 46 | Â | Â | FIV LVFLLL |
35 | W HINSTVLH | 41 | Â | Â | Â |
342 | L VFLLLADA | Â | LL FLLLADA | LL FLLLADA | LVFLLLADA |
100 | V LLAYAPRP | 50 | Â | Â | Â |
198 | F RPLLPHRL | 47 | Â | Â | Â |
218 | V RLGALVDT | 12 | Â | Â | Â |
62 | F NLLDVPKA | 45 | Â | Â | Â |
26 | L ELINTHGS | 46 | Â | Â | Â |
57 | F YYHKF NLL | 12 | FYYHKFNSSD | Â | FYYHKFNSTDD |
83 | V GPLDRCQH | 26 | Â | Â | Â |
58 | Y YHKF NLLD | 24 | Â | Â | Â |
286 | L LHSTTELA | 17 | LLHSTTEW A | Â | LLHSTTELA |
129 | V VVGTTDPK | 14 | VVVGTTDKLDD | VVVGTTDRLDD * | VVVGTTDA K |
320 | V QYLYGVGS | 46 | VQYLYGVGS | Â | VQYLYGVGS |
159 | L LVVGGLGG | 14 | Â | Â | Â |
293 | L AILPCSFT | 7 | Â | Â | LAILPCSFT |
335 | L KWEF VIL V | 4 | Â | Â | LKWEFIV LV |
322 | Y LYGVGSGM | 5 | YLYGVGSSID | Â | YLYGVGSGM |
300 | F TPMPALST | 17 | Â | Â | FTPMPALST |
245 | F YTVQGEDV | 4 | Â | Â | Â |
18 | I VRGPEQRL | 26 | Â | Â | Â |
100 | V LLAYAPRP | 4 | Â | Â | Â |
257 | V WHRFTAAC | 19 | VE HRL TAACD * | Â | Â |
206 | L LQETSRGH | 8 | Â | Â | Â |
1 | Y ITGGTAAR | 8 | Â | Â | Â |
267 | W TRGERCDI | 10 | Â | Â | WTRGERCE I |
310 | I HLHQNIVD | 11 | IHLHQNIVD * | Â | IHLHQNIVD |
NS2 | Â | Â | Â | Â | Â |
101 | V RAHVLVRL | 51 | Â | Â | VRAHVLVRL |
62 | V ILLTSLLY | 50 | Â | Â | VILLTSLLY * |
73 | L VFDIAKLL | 24 | LVFDIT KLLD * | LVFDIT KLLD * | LI FDIT KLLD |
153 | L KDLAVATE | 7 | Â | Â | LKDLAVATE * |
113 | F VRSVTGGK | 37 | Â | Â | Â |
130 | V GRWFNTYL | 11 | Â | Â | VGRWFNTYL * |
123 | F QMAILSVG | 31 | Â | Â | FQMI ILH VGD |
137 | Y LYDHLAPM | 21 | Â | Â | YLYDHLAPM |
74 | V FDIAKLLIA | 23 | VFDIT KLLL A D * | VFDIT KLLL AD | Â |
107 | LV RLCMFVR | 36 | Â | Â | LVRLCML VR |
108 | V RLCMFVRS | 51 | Â | Â | VRLCML VRS * |
89 | YF VRAHV LV | 33 | Â | Â | YFVRAHVLV |
11 | IL VLFGFFT | 15 | Â | Â | Â |
37 | Y AICRCESA | 18 | Â | IIN GLPVSAD | YT ICRCESAD * |
33 | W WNQY AICR | 8 | Â | Â | WWNQYT ICRD |
185 | I LCGLPVSA | 10 | IIN GLPVSA * | IIN GLPVSA | ILCGLPVSA |
145 | M QHWAAAGL | 18 | Â | Â | MQHWAAAGL |
50 | V PPLLARGS | 21 | Â | Â | VPS LLARGSD * |
88 | LY LIQAAIT | 35 | Â | Â | LYLIQT AITD * |
158 | V ATEPVIFS | 14 | VAV EPVV FSD | VAV EPVV FS | VATEPVIFS |
37 | Y AICRCESA | 19 | Â | Â | YTICRCESAD * |
175 | W GADTAACG | 11 | WGADTAACG * | WGADTAACG * | WGADTAACG |
NS3 | Â | Â | Â | Â | Â |
4 | V QVLSTATQ | 46 | VQIV STATQ | VQVLSSV TQD | Â |
43 | L QMYTNVDQ | 42 | Â | Â | Â |
129 | V CTRGVAKA | 21 | VCTRGVAKA | VCA RGVAKSDD * | Â |
24 | W TVYHGAGS | 13 | WTVYHGAGT | WTVYHGAGN | Â |
84 | VI PARRRGD | 18 | VIPV RRRGD * | Â | Â |
138 | L QF IPVETL | 45 | Â | Â | Â |
140 | F IPVETLST | 43 | FIPVEN LG TD | Â | Â |
6 | V LSTATQTF | 19 | IV STATQTF | Â | Â |
53 | L VGWPAPPG | 29 | LVGWPAPQ G | LVGWPS PPGD | Â |
27 | Y HGAGSRTL | 22 | YHGAGT RTI | Â | Â |
14 | F LGTTLGGV | 10 | Â | Â | Â |
77 | L VTREADVI | 25 | LVTRH ADVI D * | LVTRN ADVID * | Â |
98 | L SPRPLACL | 12 | Â | LSPRPLST LD | Â |
124 | IF RAAVCTR | 44 | Â | Â | Â |
NS4a | Â | Â | Â | Â | Â |
23 | V VIVGHIEL | 43 | VVIVGR II LDD | VVIVGR IV LDD | VVIVGHIEL |
3 | W VLLGGVL AA | 43 | WVLV GGVLAA | WVLV GGVLAA | WVLLGGVLAA |
4 | V LL GGVL AAL | 40 | VLV GGVLAAL | VLV GGVLAAL | VLLGGVLAAL |
38 | V PDKEVLY Q | 11 | Â | Â | VPDKEVLYQ * |
24 | V IVGHI ELG | 8 | Â | Â | VIVGHIELG |
10 | L AALAAY CLS | 8 | LAALAAYCLT * | LAALAAYCLS | LAALAAYCLS |
16 | Y CLSVGCV V | 6 | Â | YCLST GCVVD | YCLSVGCVV |
26 | V GHIELGGK | 9 | Â | Â | VGHIELGGK |
25 | I VGHIELGG | 29 | Â | Â | IVGHIELGG |
20 | V GCVVIVGH | 15 | Â | Â | VGCVVIVGH |
9 | VL AALAAY C | 9 | VLAALAAYC* | VLAALAAYC | VLAALAAYC |
29 | I ELGGKPAL | 14 | Â | Â | IELGGKPAL |
NS4b | Â | Â | Â | Â | Â |
81 | FF NILGGWV | 41 | Â | Â | FFNILGGWV |
153 | V NLLPAILS | 51 | VNLLPAILS | VNLLPAILS | VNLLPAILS |
152 | VV NLLPAIL | 51 | Â | Â | Â |
39 | W NF VSGI QY | 16 | WNFI SGIQY | WNFI SGIQY | WNFVSGIQY |
165 | L VVGVICAA | 35 | LVVGVV CAA | LVVGVV CAA | LVVGVICAA |
82 | F NILGGWVA | 32 | FNILGGWVA | FNILGGWVA | FNILGGWVA |
81 | FF NILGGWV | 5 | Â | Â | FFNILGGWV |
63 | LM AFAASVT | 9 | LMAFT ASI TD | LMAFT AA VTDD | LMAFT ASVTD |
27 | W QKLEAFWH | 35 | Â | WQKLEV FWAD | WQKLEAFWH * |
167 | V GVICAALL | 11 | VGVV CAAI L | VGVV CAAI L | VGVICAAI L |
45 | I QYLAGLST | 35 | IQYLAGLST | IQYLAGLST | IQYLAGLST |
64 | M AFAASVTS | 23 | MAFT ASI TS | MAFT AA VTSDD | MAFT ASVTSD |
84 | I LGGWVATH | 24 | ILGGWVAAQDD | ILGGWVAAQDD | ILGGWVATH |
103 | VV SGLAGAA | 10 | Â | VGA GLAGAAD | VVSGLAGAA |
166 | VV GVICAAL | 31 | VVGVV CAAI | VVGVV CAAI | VGVICAAI L |
85 | L GGWVATHL | 3 | LGGWVAAQ LDD | LGGWVAAQ LDD | LGGWVATHL |
60 | V ASLMAFAA | 15 | Â | Â | VASLMAFT AD |
41 | F VSGI QYLA | 8 | FI SGIQYLA | FI SGIQYLA | FVSGIQYLA |
139 | F KIMGGELP | 21 | Â | FKIMS GEV PD | FKIMGGEF P * |
9 | L QRATQQQA | 14 | Â | Â | LQRATQQQA * |
122 | L DILAGYGA | 6 | Â | Â | LDILAGYGA * |
104 | V SGLAGAAI | 3 | Â | Â | VSGLAGAAI |
NS5a_1a | Â | Â | Â | Â | Â |
39 | M RLAGPRTC | 51 | MRIV GPRTC * | FISCQKGYRD * | MRLAGPRTC* |
3 | F ISCQKGYK | 22 | FF SCQR GYKDD * | Â | FISCQKGYK * |
19 | V VSTRCPCG | 25 | Â | Â | VM STRCPCG * |
NS5a_1b | Â | Â | Â | Â | Â |
73 | L LRDEITF V | 20 | LLRDEV TFQD* | LLRDEV TFQ D ** | LLRDEITFV * |
16 | W RVAANSYV | 33 | WRVAAEE YVDD * | WRVAASE YVD | WRVAANSYV |
55 | F TEVDGVRL | 4 | FTEL DGVRL* | FTEVDGVRL ** | FTEVDGVRL |
80 | FV VGLNSYA | 25 | Â | Â | FVVGLNSYA * |
32 | F HYITGATE | 16 | Â | Â | FHYITGATE |
61 | V RLHRYAPP | 27 | VRLHRYAPA* | Â | VRLHRYAPP * |
87 | Y AIGSQLPC | 20 | YVV GSQLPC * | VRLHRYAPAD ** | YAIGSQLPC * |
23 | YV EVRRVGD | 14 | YVEVT RVGDD * | YVEVT RVGDD ** | YVEVRRVGD |