A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation

Table 3 Prognosis accuracies of combined serum markers

Markers	Study	Year	Prognosis	Sen	Spe	PPV	NVP	AUC
FIB-4	Sterling [122]	2006	Fibrosis	70	74	42	71	0.80
			Cirrhosis
	De Ledingh [82]	2006	Cirrhosis	-	-	-	-	0.73
	Vallet-Pichard [123]	2007	Fibrosis	74	80	82	95	0.85
	Cales [85]	2008	Fibrosis	74	72	74	71	0.80
			Cirrhosis	-	-	-	-	0.87
	Mallet [124]	2009	Fibrosis	71	73	52	86	0.81
			Cirrhosis	-	-	-	-	0.87
	Lee [107]	2010	Cirrhosis	-	-	-	-	0.71
Fibrometer	Halfon [83]	2007	Fibrosis	92	87	21	100	0.94
			Cirrhosis	62	87	21	100	0.94
	Cales [85]	2008	Fibrosis	-	-	-	-	0.90
			Cirrhosis	-	-	-	-	0.90
	Cales [105]	2010	Fibrosis	-	-	-	-	0.88
			Cirrhosis	-	-	-	-	0.88
Fortunato Score	Fortunato [127]	2001	Fibrosis	-	94	-	-	-
HepaScore	Adams [117]	2005	Fibrosis	63	89	88	90	0.82
			Cirrhosis	71	89	-	-	0.90
	Bourliere [80]	2006	Fibrosis	-	-	-	-	0.82
			Cirrhosis	-	-	-	-	0.90
	Halfon [83]	2007	Fibrosis	77	63	59	80	0.76
			Cirrhosis	92	72	11	100	0.89
	Leroy [118]	2007	Fibrosis	54	84	78	64	0.79
	Leroy [84]	2008	Fibrosis	63	80	75	70	0.78
	Cales [85]	2008	Fibrosis	66	79	77	68	0.78
			Cirrhosis	-	-	-	-	0.90
	Becker [119]	2009	Fibrosis	82	65	70	78	0.81
			Cirrhosis	-	-	-	-	0.88
	Cales [105]	2010	Fibrosis	-	-	-	-	0.78
			Cirrhosis	-	-	-	-	0.89
	Guechot [120]	2010	Fibrosis	77	70	71	77	0.81
			Cirrhosis	86	74	37	97	0.88
Shasta Index	Kelleher [121]	2005	Fibrosis	88	72	55	94	0.87
Sud Index	Sud [125]	2004	Fibrosis	42	98	97	54	0.84
Testa Index	Testa [126]	2006	Fibrosis	78	79	-	-	0.80

ISSN: 1743-422X