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Table 3 Prognosis accuracies of combined serum markers

From: A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation

Markers Study Year Prognosis Sen Spe PPV NVP AUC
FIB-4 Sterling [122] 2006 Fibrosis 70 74 42 71 0.80
    Cirrhosis      
  De Ledingh [82] 2006 Cirrhosis - - - - 0.73
  Vallet-Pichard [123] 2007 Fibrosis 74 80 82 95 0.85
  Cales [85] 2008 Fibrosis 74 72 74 71 0.80
    Cirrhosis - - - - 0.87
  Mallet [124] 2009 Fibrosis 71 73 52 86 0.81
    Cirrhosis - - - - 0.87
  Lee [107] 2010 Cirrhosis - - - - 0.71
Fibrometer Halfon [83] 2007 Fibrosis 92 87 21 100 0.94
    Cirrhosis 62 87 21 100 0.94
  Cales [85] 2008 Fibrosis - - - - 0.90
    Cirrhosis - - - - 0.90
  Cales [105] 2010 Fibrosis - - - - 0.88
    Cirrhosis - - - - 0.88
Fortunato Score Fortunato [127] 2001 Fibrosis - 94 - - -
HepaScore Adams [117] 2005 Fibrosis 63 89 88 90 0.82
    Cirrhosis 71 89 - - 0.90
  Bourliere [80] 2006 Fibrosis - - - - 0.82
    Cirrhosis - - - - 0.90
  Halfon [83] 2007 Fibrosis 77 63 59 80 0.76
    Cirrhosis 92 72 11 100 0.89
  Leroy [118] 2007 Fibrosis 54 84 78 64 0.79
  Leroy [84] 2008 Fibrosis 63 80 75 70 0.78
  Cales [85] 2008 Fibrosis 66 79 77 68 0.78
    Cirrhosis - - - - 0.90
  Becker [119] 2009 Fibrosis 82 65 70 78 0.81
    Cirrhosis - - - - 0.88
  Cales [105] 2010 Fibrosis - - - - 0.78
    Cirrhosis - - - - 0.89
  Guechot [120] 2010 Fibrosis 77 70 71 77 0.81
    Cirrhosis 86 74 37 97 0.88
Shasta Index Kelleher [121] 2005 Fibrosis 88 72 55 94 0.87
Sud Index Sud [125] 2004 Fibrosis 42 98 97 54 0.84
Testa Index Testa [126] 2006 Fibrosis 78 79 - - 0.80