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Table 2 Diagnostic accuracies of indirect serum markers

From: A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation

Markers Study Year Prognosis Sen Spe PPV NVP AUC
AAR Sheth [74] 1998 Cirrhosis 53 100 100 81 0.85
  Afdhal [4] 2004 Fibrosis 47 - - 88 -
    Cirrhosis - 96 74 - -
  Lackner [70] 2005 Fibrosis 53 100 - - 0.57
    Cirrhosis 36 90 41 87 0.73
  Fuji [77] 2009 Fibrosis - - - - 0.56
ActiTest Imbert-Bismut [26] 2001 Fibrosis 91 42 - - 0.79
  Halfon [100] 2008 Fibrosis 90 38 - - 0.75
APRI Wai [28] 2003 Fibrosis 41 95 64 90 0.88
    Cirrhosis - - 57 - 0.94
  Cales [79] 2005 Fibrosis - - - - 0.79
  Bourliere [80] 2006 Fibrosis 22 95 63 76 0.71
    Cirrhosis 38 96 96 40 0.81
  Parise [81] 2006 Fibrosis 85 66 - - 0.82
    Cirrhosis 73 81 - - 0.84
  De Ledinghen [82] 2006 Cirrhosis - - - - 0.73
  Halfon [83] 2007 Fibrosis 77 66 61 80 0.76
    Cirrhosis 100 83 18 100 0.92
  Leroy [84] 2008 Fibrosis 39 95 88 62 0.79
  Cales [85] 2008 Fibrosis 62 83 80 67 0.78
    Cirrhosis - - - - 0.84
  Kamphues [86] 2010 Fibrosis 70 63 80 80 0.68
    Cirrhosis 89 44 14 97 0.63
  Fuji [77] 2009 Cirrhosis - - - - 0.76
Fibro Index Koda [106] 2007 Fibrosis 36 97 94 59 0.83
Fibrosis Index Ohta [113] 2006 Fibrosis 68 71 75 81 0.85
FibroTest Imbert-Bismut [26] 2001 Fibrosis 87 59 63 85 0.87
    Cirrhosis      
  Bedosa [102] 2003 Fibrosis 27 97 90 55 -
  Myers [101] 2003 Fibrosis - 95 88 - 0.83
  Poynard [90] 2003 Fibrosis - - - - 0.73
  Rossi [97] 2003 Fibrosis 83 52 52 83 0.74
  Colletta [103] 2005 Fibrosis 64 31 33 62 -
  Bourliere [80] 2006 Fibrosis 55 90 73 79 0.82
  De Ledinghen [82] 2006 Cirrhosis - - - - 0.73
  Halfon [83] 2007 Fibrosis 67 80 70 78 0.79
    Cirrhosis 85 74 11 99 0.86
  Leroy [84] 2008 Fibrosis 57 85 78 68 0.80
  Cales [85] 2008 Fibrosis 67 82 80 70 0.81
  Shaheen [104] 2008 Fibrosis 47 90 - - 0.81
    Cirrhosis - - - - 0.90
  Cales [105] 2010 Fibrosis - - - - 0.81
    Cirrhosis - - - - 0.88
Forn's Index Forn [27] 2002 Fibrosis 94 51 40 96 0.78
  Cales [79] 2005 Fibrosis - - - - 0.82
  Bourliere [80] 2006 Fibrosis 30 96 65 83 0.76
  Koda [106] 2007 Fibrosis - - - - 0.79
Model 3 Lok [110] 2005 Cirrhosis 10 100 100 86 0.78
PGA Teare [87] 1993 Fibrosis 94 81 - - -
    Cirrhosis - - 86 - -
  Poynard [90] 2003 Fibrosis 91 81 - - -
  Poynard [91] 2004 Fibrosis 79 89 - - -
PGAA Naveau [92] 2005 Cirrhosis 89 79 - - 0.93
Phol Score Pohl [114] 2001 Fibrosis 41 99 93 85 -
  Cheung [115] 2008 Fibrosis - - - - 0.53