A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation

Ahmad, Waqar; Ijaz, Bushra; Gull, Sana; Asad, Sultan; Khaliq, Saba; Jahan, Shah; Sarwar, Muhammad T; Kausar, Humera; Sumrin, Aleena; Shahid, Imran; Hassan, Sajida

doi:10.1186/1743-422X-8-53

Virology Journal

Table 2 Diagnostic accuracies of indirect serum markers

From: A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation

Markers	Study	Year	Prognosis	Sen	Spe	PPV	NVP	AUC
AAR	Sheth [74]	1998	Cirrhosis	53	100	100	81	0.85
	Afdhal [4]	2004	Fibrosis	47	-	-	88	-
			Cirrhosis	-	96	74	-	-
	Lackner [70]	2005	Fibrosis	53	100	-	-	0.57
			Cirrhosis	36	90	41	87	0.73
	Fuji [77]	2009	Fibrosis	-	-	-	-	0.56
ActiTest	Imbert-Bismut [26]	2001	Fibrosis	91	42	-	-	0.79
	Halfon [100]	2008	Fibrosis	90	38	-	-	0.75
APRI	Wai [28]	2003	Fibrosis	41	95	64	90	0.88
			Cirrhosis	-	-	57	-	0.94
	Cales [79]	2005	Fibrosis	-	-	-	-	0.79
	Bourliere [80]	2006	Fibrosis	22	95	63	76	0.71
			Cirrhosis	38	96	96	40	0.81
	Parise [81]	2006	Fibrosis	85	66	-	-	0.82
			Cirrhosis	73	81	-	-	0.84
	De Ledinghen [82]	2006	Cirrhosis	-	-	-	-	0.73
	Halfon [83]	2007	Fibrosis	77	66	61	80	0.76
			Cirrhosis	100	83	18	100	0.92
	Leroy [84]	2008	Fibrosis	39	95	88	62	0.79
	Cales [85]	2008	Fibrosis	62	83	80	67	0.78
			Cirrhosis	-	-	-	-	0.84
	Kamphues [86]	2010	Fibrosis	70	63	80	80	0.68
			Cirrhosis	89	44	14	97	0.63
	Fuji [77]	2009	Cirrhosis	-	-	-	-	0.76
Fibro Index	Koda [106]	2007	Fibrosis	36	97	94	59	0.83
Fibrosis Index	Ohta [113]	2006	Fibrosis	68	71	75	81	0.85
FibroTest	Imbert-Bismut [26]	2001	Fibrosis	87	59	63	85	0.87
			Cirrhosis
	Bedosa [102]	2003	Fibrosis	27	97	90	55	-
	Myers [101]	2003	Fibrosis	-	95	88	-	0.83
	Poynard [90]	2003	Fibrosis	-	-	-	-	0.73
	Rossi [97]	2003	Fibrosis	83	52	52	83	0.74
	Colletta [103]	2005	Fibrosis	64	31	33	62	-
	Bourliere [80]	2006	Fibrosis	55	90	73	79	0.82
	De Ledinghen [82]	2006	Cirrhosis	-	-	-	-	0.73
	Halfon [83]	2007	Fibrosis	67	80	70	78	0.79
			Cirrhosis	85	74	11	99	0.86
	Leroy [84]	2008	Fibrosis	57	85	78	68	0.80
	Cales [85]	2008	Fibrosis	67	82	80	70	0.81
	Shaheen [104]	2008	Fibrosis	47	90	-	-	0.81
			Cirrhosis	-	-	-	-	0.90
	Cales [105]	2010	Fibrosis	-	-	-	-	0.81
			Cirrhosis	-	-	-	-	0.88
Forn's Index	Forn [27]	2002	Fibrosis	94	51	40	96	0.78
	Cales [79]	2005	Fibrosis	-	-	-	-	0.82
	Bourliere [80]	2006	Fibrosis	30	96	65	83	0.76
	Koda [106]	2007	Fibrosis	-	-	-	-	0.79
Model 3	Lok [110]	2005	Cirrhosis	10	100	100	86	0.78
PGA	Teare [87]	1993	Fibrosis	94	81	-	-	-
			Cirrhosis	-	-	86	-	-
	Poynard [90]	2003	Fibrosis	91	81	-	-	-
	Poynard [91]	2004	Fibrosis	79	89	-	-	-
PGAA	Naveau [92]	2005	Cirrhosis	89	79	-	-	0.93
Phol Score	Pohl [114]	2001	Fibrosis	41	99	93	85	-
	Cheung [115]	2008	Fibrosis	-	-	-	-	0.53

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ISSN: 1743-422X

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