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Table 1 Diagnostic accuracies of direct serum markers

From: A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation

Markers Study Year Prognosis Sen Spe PPV NVP AUC
ELF Score Rosenberg [44] 2004 Fibrosis 90 41 99 92 0.80
    Cirrhosis - - - - 0.89
  Cales [79] 2005 Fibrosis - - - - 0.88
  Parkes [12] 2006 Fibrosis - - - - 0.78
  Lee [107] 2010 Cirrhosis      0.70
FibroSpect Patel [42] 2004 Fibrosis 77 73 74 75 0.83
  Cales [79] 2005 Fibrosis - - - - 0.87
  Zaman [43] 2007 Fibrosis 72 74 61 82 0.82
HA Guechot [34] 1996 Fibrosis 64 91 - - 0.86
    Cirrhosis 79 89 - - 0.92
  Murawaki [47] 2001 Fibrosis 75 80 77 78 0.86
    Cirrhosis 50 79 42 84 0.92
  Halfon [49] 2005 Fibrosis 14 99 94 57 0.75
    Cirrhosis 31 99 57 96 0.89
  Suzuki [48] 2005 Fibrosis 85 80 51 96 0.89
    Cirrhosis - - - - 0.92
  Saitou [51] 2005 Fibrosis 80 80 80 80 0.92
  Parise [81] 2006 Fibrosis 85 71 - - 0.88
    Cirrhosis 91 82 - - 0.91
Leroy Score Leroy [45] 2004 Fibrosis 43 64 45 40 -
PIIINP Guechot [34] 1996 Fibrosis 70 63 - - 0.69
    Cirrhosis 60 74 - - 0.73
  Murawaki [47] 2001 Fibrosis 74 75 75 92 -
    Cirrhosis 64 59 33 84 -
  Saitou [51] 2005 Fibrosis 78 75 76 77 0.75
    Cirrhosis 77 66 69 67 0.79
PIVNP Murawaki [47] 2001 Fibrosis 70 73 71 72 -
    Cirrhosis 63 73 41 87 -
TIMP Murawaki [47] 2001 Fibrosis 79 56 63 73 -
    Cirrhosis 82 54 34 94 -
  Boeker [38] 2002 Fibrosis 52 88 - - 0.71
    Cirrhosis 100 75 - - 0.90
YKL-40 Saitou [51] 2005 Fibrosis 78 81 80 79 0.81
    Cirrhosis 80 71 73 78 0.80