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Table 5 Comparison between obese and non-obese patients (CHC and HCC)

From: Chronic hepatitis c genotype-4 infection: role of insulin resistance in hepatocellular carcinoma

Variables

Obese

N = 42

N(%)

Non-obese

N = 58

N(%)

P-value

Age

60 (36-76)

57(34-73)

0.168

Biochemical tests Median(Range),

   

ALT (IU/L)

60 (36-180)

60(25-103)

0.817

AST (IU/L)

93.5(34-310)

90(25-300)

0.115

T. Bil (mg/dL)

2.1(0.6-4.5)

1.9(0.5-6)

0.092

Albumin (g/dL)

3.1(1.6-4.2)

3.2(1.6-4.2)

0.262

INR

1.2(0.8-1.5)

1.1(0.7-1.5)

<0.001

GGT (IU/L)

83.5(25-560)

71(15-500)

0.043

Fasting Glu (mg/dL)

190((96-890)

150 (76-870)

<0.001

Fasting Ins (IU/mL)

10(6-14)

7.6 (3.5-15)

<0.001

HbA1c (%)

8.6(5.2-12)

6.6 (3.2-13)

<0.001

HOMA-IR

4.8(1.66-28.5)

2.37(0.86-32.22)

<0.001

Plt (x109/L)

140(50-250)

140 (60-300)

0.018

Cholesterol (mg/dL)

220(160-300)

187 (110-250)

<0.001

TG (mg/dL)

212(150-300)

180 (87-220)

<0.001

Tumor marker median(range)

   

Serum AFP (ng/mL)

115(6-1060)

181(5-560)

0.229

HCV RNA (viral load copies/IU/L) N(%)

   

Low (< 100 × 103)n = 21

2(4.8)

19 (32.8)

0.001

Moderate (100-1000 × 103) n = 56

25(59.5)

31 (53.4)

 

High (>1000 × 103) n = 23

15(35.7)

8 (13.8)

0.001

Stage of Fibrosis N(%)

   

I+II (n = 17)

2 (12)

15 (88)

0.02

III+IV+ V (n = 83)

40 (48)

43 (52)

 
  1. ALT, alanine aminotransferase; AST, aspartate aminotransferase, INR, International normalization ratio (for blood clotting); GGT, gammaglutamyl transferase; Glu, glucose; Ins, insulin; HbA1c, glycosylated hemoglobin; HOMA-IR, Homeostasis Model for Assessment of Insulin Resistance; Plt, platelet count; TG, triglycerides; AFP, alpha fetoprotein;