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Table 1 Odds of fatal outcome by LASV-specific NP Ag- and Ab-capture ELISA

From: Emerging trends in Lassa fever: redefining the role of immunoglobulin M and inflammation in diagnosing acute infection

Test Result N (% fatal) Comparison Group Adjusted OR (95% CI)a p
Ag+IgM+ 35 (54) Ag-IgM+ 4.33* (2.01, 9.30) < 0.01
Ag+IgM- 96 (56) Ag-IgM- 5.36* (3.19, 9.00) < 0.01
   Ag+IgM+ 1.09 (0.50, 2.40) 0.83
Ag-IgM+ 171 (22) Ag-IgM- 1.13 (0.70, 1.83) 0.61
Ag-IgM- 244 (20) - - -
  1. a Odds of fatal outcome relative to the comparison group; all Ors are adjusted for gender.
  2. * Statistically significant at the 5% significance level.
  3. Individuals who presented to the KGH LFW were tested for LF by Ag- and Ab-capture ELISA. We subsequently categorized individuals based on LASV Ag and Ab status. Fatality comparisons of Ag+IgM+, Ag+IgM-, Ag-IgM+, and Ag-IgM- individuals revealed that there was no significant difference between Ag-status groups irrespective of IgM status. Conversely, Ag+ patients were about 5 times more likely to succumb than Ag- patients irrespective of IgM status (p < 0.01).