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Table 1 Neutralizing antibody responses against HTNV in mice 21 days after 1st vaccination

From: Fusion with extracellular domain of cytotoxic T-lymphocyte-associated-antigen 4 leads to enhancement of immunogenicity of Hantaan virus DNA vaccines in C57BL/6 mice

   Titers for 50% neutralization
Vaccination groups Mouse no. Day 0 Day 21
CpG+pcDNA3/eCTLA4-S+M 1 < 8 16
  2 < 8 32
  3 < 8 32
  4 < 8 16
  5 < 8 16
pcDNA3/eCTLA4-S+M 1 < 8 16
  2 < 8 16
  3 < 8 16
  4 < 8 16
  5 < 8 32
CpG+pcDNA3/S+M 1 < 8 16
  2 < 8 16
  3 < 8 16
  4 < 8 16
  5 < 8 16
pcDNA3/S+M 1 < 8 16
  2 < 8 16
  3 < 8 16
  4 < 8 8
  5 < 8 8
pcDNA3 1 < 8 < 8
  2 < 8 < 8
  3 < 8 < 8
  4 < 8 < 8
  5 < 8 < 8