Identification of novel conserved functional motifs across most Influenza A viral strains

Table 3 Evolutionary highly conserved motifs in Influenza A virus

Segment	Motif	Length	start position (consensus sequence)	End Position (Consensus Sequence)	H5N1 Start Position	H5N1 End Position	Sequence	Repeated Positions On H5N1	Mapping on Conserved Regions
1 (PB2)	1	9	1652	1660	1631	1639	TGATGTGGG		R8
1 (PB2)	2	6	2254	2259	2232	2237	GAAACG	(2238 - 2243)	R12
1 (PB2)	3	11	2273	2283	2251	2261	AGCATACTTAC		R12
1 (PB2)	4	9	2291	2299	2269	2277	CAGACAGCG		R12
1 (PB2)	1	6	914	919	889	894	ATGATG	(1243 - 1248) (1246 - 1251) (1624 - 1629) (1994 - 1999)	R8
2 (PB1)	2	11	1268	1278	1243	1253	ATGATGATGGG		R10
2 (PB1)	3	6	2354	2359	2248	2253	GAGATC	(101 to 106)	R23, R25
2 (PB1)	4	6	2391	2396	2285	2290	GACGGC		R24, R25
3 (PA)	1	8	2140	2147	2095	2102	GAGGAGTG		R18
3 (PA)	2	6	2150	2155	2105	2110	TGATTA		R18
7 (M)	1	9	93	101	77	85	GGCCCCCTC		R1
7 (M)	2	11	180	190	164	174	AAGACAAGACC		R1
7 (M)	3	8	196	203	180	187	TGTCACCT		R1
7(M)	4	17	237	253	221	237	CTCACCGTGCCCAGTGA		R2
7 (M)	5	7	873	879	855	861	TTCAAAT		R8
7 (M)	6	8	945	952	927	934	ATGAGGGA		R8
8 (NS)	1	7	69	75	43	49	AGGTAGA		R1
8 (NS)	2	10	574	583	529	538	AGGATGTCAA		R6
8 (NS)	3	6	616	621	571	576	AATGGA	( 368- 373) (383- 388)	R6

The evolutionary conserved motifs found in four of the eight influenza segments, whose criteria are at least 6 consecutive nucleotides that are 100% conserved in all the studied strains and the location of each motif on H5N1 Refseq. Sequences and length are shown

ISSN: 1743-422X