Figure 4

Hypothetical model for the end replication of the linear Mimivirus genome. The Mimvirus genome is illustrated by two black lines with arrowheads indicating the 3'-ends. Inverted repeats are indicated by black (forward) and gray (reverse) bars. Red triangle indicates the position of the putative origin of replication corresponding to the 400,000 nt position, where gene excess and A+C excess curves show a reversal. Green sold lines indicate newly synthesized leading strands, and green dotted lines newly synthesized lagging strands. The R555 gene product is hypothesized to be involved in the DSB resection. 3' ss end then invades the homologous duplex at the opposite extremity of the genome, and the DNA synthesis starts (solid red line for leading and dotted red line for lagging strand synthesis). Cross-strand structure is resolved by cleavages (blue triangles).