Skip to main content

Table 2 Amino acid variations at critical sites of HA and NA proteins of the H5N1 viruses that determining virus phenotype

From: A molecular and antigenic survey of H5N1 highly pathogenic avian influenza virus isolates from smallholder duck farms in Central Java, Indonesia during 2007-2008

  

HAa

NAb

  

Receptor Binding Site

Antigenic site

Glycosylation site

Residues prior to

cleavage site

NA-active site

Stalk

deletion

Residues

resistant to NA

inhibitors

Virus namec

Statusd

 

Site A

Site B

Site E

              
  

189

217

138

140

141

124

83

86

154

155

156

323

324

325

326

327

328

329

330

223

49-68

 

Dk/BT/678-24404/07

Live

R

S

L

S

P

D

A

T

N

S

T

R

E

S

R

R

K

R

R

I

YES

NO

Dk/BT/678-2D403/07

Live

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

nd

nd

nd

Ck/BT/627-23296/07

Dead

-

-

-

-

-

-

-

I

-

-

-

-

-

-

-

-

-

K

-

nd

nd

nd

Ck/BT/446-24454/07

Dead

-

-

-

-

-

-

-

I

-

-

-

-

-

-

-

-

-

K

-

-

YES

NO

Ck/BT/446-24452/07

Dead

-

-

-

-

-

-

-

I

-

-

-

-

-

-

-

-

-

K

-

nd

nd

nd

Ck/BT/446-24453/07

Dead

-

-

-

-

-

-

-

I

-

-

-

-

-

-

-

-

-

K

-

nd

nd

nd

Dk/BT/387-23310/07

Live

K

-

-

T

-

-

V

A

-

-

-

-

-

R

-

-

-

K

-

V

YES

NO

Dk/BT/387-23310x1/07

Live

K

-

-

T

-

-

V

A

-

-

-

-

-

R

-

-

-

K

-

nd

nd

nd

Dk/BT/387-23310x2/07

Live

K

-

-

T

-

-

V

A

-

-

-

-

-

R

-

-

-

K

-

nd

nd

nd

Dk/BT/224-24466/07

Dead

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

nd

nd

nd

Dk/BT/78-22210/08

Dead

-

-

-

-

-

-

-

-

-

-

-

K

-

-

-

-

-

K

-

-

YES

NO

Ck/KP/607-605/07

Dead

-

P

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

K

-

-

YES

NO

Ck/KP/610-11019/07

Dead

-

-

-

R

-

-

-

-

-

-

-

-

-

-

-

-

-

K

-

nd

nd

nd

Ck/KP/610-11020/07

Dead

-

-

-

R

-

-

-

-

-

-

-

-

-

-

-

-

-

K

-

nd

nd

nd

Dk/KP/618-11001/07

Live

-

-

-

-

-

-

-

I

-

-

-

-

-

-

-

-

-

K

-

-

YES

NO

Dk/KP/618-11003/07

Live

-

-

-

-

-

-

-

I

-

-

-

-

-

-

-

-

-

K

-

nd

nd

nd

Dk/KP/618-11009/07

Live

-

-

-

-

-

-

-

I

-

-

-

-

-

-

-

-

-

K

-

nd

nd

nd

Ck/KP/822-545/07

Dead

-

-

-

-

-

-

-

I

-

-

-

-

-

-

-

-

-

K

-

nd

nd

nd

Ck/KP/922-511/07

Dead

-

-

-

-

-

G

-

I

-

-

-

-

-

-

-

-

-

K

-

-

YES

NO

Ck/SM/626-233/07

Dead

-

-

-

R

-

-

-

-

-

-

-

-

-

-

-

-

-

K

-

-

YES

NO

Ck/SM/626-234/07

Dead

-

-

-

R

-

-

-

-

-

-

-

-

-

-

-

-

-

K

-

nd

nd

nd

Dk/SM/679-31024/07

Dead

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

nd

nd

nd

Dk/SM/1003-34368/07

Dead

-

-

Q

K

S

-

-

A

-

-

-

-

-

R

-

-

-

K

-

-

YES

NO

Ck/SM/82-65/08

Dead

-

-

-

-

-

-

-

-

-

-

-

K

-

-

-

-

-

K

-

nd

nd

nd

Ck/MG/662-763/07

Dead

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

R

K

-

nd

nd

nd

Ck/MG/680-74X/07

Dead

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

R

K

-

-

YES

NO

Dk/MG/680-41041/07

Live

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

nd

nd

nd

Dk/MG/680-41044/07

Live

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

YES

NO

Ck/MG/680-744/07

Dead

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

nd

nd

nd

Dk/MG/24-44380/08

Live

-

-

-

-

-

-

-

-

-

N

-

-

-

-

-

-

-

K

-

-

YES

NO

Other isolatese

mix

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

K

-

-

YES

NO

  1. Amino acid sequence is shown for 30 (HA) and 13 (NA) individual H5N1 viruses. Abbreviation: chicken (Ck), duck (Dk), Bantul (BT), Kulon Progo (KP), Sleman (SM), Magelang (MG), not done (nd).
  2. a H5 numbering is based on the HA protein sequence of A/Goose/Guangdong/1/96 (H5N1) minus the signal peptide.
  3. b N1 numbering starts from the initiating codon residue (methionine) of the NA gene.
  4. c The letters 'BBVW' have been removed from the virus names.
  5. d Status indicates the clinical presentation of birds when samples were collected.
  6. e The remaining isolates had identical sequence in the amino acids of HA (54) and NA (11), respectively.
Back to article page

Virology Journal

ISSN: 1743-422X