Figure 7

Illustration of the Interaction of IκBα ankyrins with NF-κB. NF-κB p65/p50 dimer subunits (red shadings) are shown bound to ankyrin repressor IκBα. IκBα ankyrin domains 3 (green) and 4 (yellow) are shown in color while other regions of the IκBα protein are shown in grey. Each ankyrin unit is composed of a structurally conserved alpha helix dimer backbone, and a less structurally conserved loop region inserting into the NF-κB p65/p50 groove.